Results 211 to 220 of about 50,225 (239)

Different Contribution of Missense and Loss‐of‐Function Variants to the Genetic Structure of Familial and Sporadic Meniere Disease

open access: yesMedComm, Volume 6, Issue 10, October 2025.
This study examines the genetic basis of sporadic (SMD) and familial Meniere disease (FMD) by comparing rare protein‐coding variants using exome sequencing and gene burden analysis. FMD patients had a higher accumulation of missense and LoF variants, especially in genes linked to auditory and vestibular function.
Alberto M. Parra‐Perez   +5 more
wiley   +1 more source

Membranous Labyrinth Position in the Lateral Semicircular Canal: Considerations for Gene Therapy Delivery

open access: yesOTO Open, Volume 9, Issue 4, October-December 2025.
Abstract Introduction Fenestration of the lateral semicircular canal has been proposed to improve intracochlear gene therapy delivery, but the relationship between the membranous and bony labyrinths at the canal apex has not been systematically defined.
Koffi L. Lakpa   +11 more
wiley   +1 more source

Long‐Term Clinical Outcome and Quality of Life of Children, Adolescents, and Young Adults With Chordoma or Chondrosarcoma Treated With Pencil Beam Scanning Proton Therapy

open access: yesPediatric Blood &Cancer, Volume 72, Issue 10, October 2025.
ABSTRACT Background and Aims To assess clinical outcomes and quality of life (QoL) of children, adolescents, and young adults (C‐AYAs) with chordomas (CH) or chondrosarcomas (CS) after pencil beam scanning proton therapy (pbsPT). Methods A total of 76 C‐AYAs treated between 1999 and 2023 were included. Median age was 16.6 years (1.5–25.4).
Miriam Vazquez   +5 more
wiley   +1 more source

The fine structure and organization of tip links on hair cell stereovilli [PDF]

open access: yes, 1988
Brix, Jutta   +6 more
core  

The Transcriptome Trajectory Reveals Sex‐ and Age‐Dependent Changes in the Mouse Adrenal Gland

open access: yesAging Cell, Volume 24, Issue 10, October 2025.
This comprehensive RNA‐seq dataset reveals the sex‐ and age‐dependent gene expression profile of the mouse adrenal gland. It helps identify novel marker genes of the adrenal inner cortex, offering new insights into the organ's development and aging process.
Hui Wang   +4 more
wiley   +1 more source

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