Results 211 to 214 of about 10,621 (214)
VDAC1 Inhibition Protects Against Noise‐Induced Hearing Loss via the PINK1/Parkin Pathway
CNS Neuroscience &Therapeutics, Volume 31, Issue 4, April 2025.VDAC1 is expressed in cochlear hair cells and its expression is increased after noise exposure. Inhibiting VDAC1 by DIDS protects cochlear hair cells and synaptic ribbons from noise‐induced damage in C57BL/6 mice. VDAC1 inhibition reduces ROS levels and inflammation in cochlear hair cells after noise.
Yuchen Jin +5 more
wiley +1 more source
Direct reprogramming of fibroblasts into spiral ganglion neurons by defined transcription factors
Cell Proliferation, Volume 58, Issue 4, April 2025.A combination of Ascl1, Pou4f1 and Myt1l was identified to promote functional reprogramming of cochlear spiral ganglion neurons based on biochemical, electrophysiological and single‐cell transcriptomic analyses. Abstract Degeneration of the cochlear spiral ganglion neurons (SGNs) is one of the major causes of sensorineural hearing loss and ...
Yuhang Huang +11 more
wiley +1 more source
INFLUENCE ON THE COCHLEA OF GUINEA PIG BY LONG TERMED EXPOSURE OF BAND NOISE
, 1977 Noboru Yamada
openalex +2 more sources
Cell Proliferation, Volume 58, Issue 4, April 2025.This work investigated the in vivo role of Net1 in cochlear hair cell (HC) regeneration. Conditional overexpression of Net1 in Lgr5+ progenitors of neonatal mouse cochlea enhance HC regeneration by inducing direct trans‐differentiation of Lgr5+ progenitors into HCs probably via activation of Atoh1, Gfi1, and Pou4f3 transcription factors.
Yanqin Lin +10 more
wiley +1 more source