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Pravastatin attenuates noise-induced cochlear injury in mice
Neuroscience, 2012Noise-induced hearing loss (NIHL) is one of the most common forms of sensorineural hearing loss and a well-known contributor to presbycusis. Based on the generation of reactive oxygen species (ROS) in the pathogenesis of NIHL, augmentation of the antioxidative defense system is a major target for pharmacological prevention.
J S, Park +5 more
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Hearing Research, 2014
The dynamics of cochlear excitotoxicity can be monitored from effects on the contralateral ear. After unilateral mechanical ablation of the cochlea (in a mouse model) we observed immediate elevations in auditory brainstem evoked response (ABR) thresholds in the contralateral ear.
Jaina, Negandhi +3 more
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The dynamics of cochlear excitotoxicity can be monitored from effects on the contralateral ear. After unilateral mechanical ablation of the cochlea (in a mouse model) we observed immediate elevations in auditory brainstem evoked response (ABR) thresholds in the contralateral ear.
Jaina, Negandhi +3 more
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Calcium concentration in cochlear endolymph after vestibular labyrinth injury
NeuroReport, 2010The endolymphatic calcium concentration [Ca2+] is essential for acoustic transduction. This study investigated the changes in cochlear function caused by vestibular labyrinth destruction in the acute phase by measurement of the endocochlear potential and endolymphatic [Ca2+].Hartley guinea pigs underwent lateral semicircular canal transection with ...
Ryoukichi, Ikeda +4 more
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Inhibition of Post‐Meningitic Cochlear Injury with Cerebrospinal Fluid Irrigation
Otolaryngology–Head and Neck Surgery, 2006OBJECTIVELabyrinthitis ossificans, the pathologic ossification of the otic capsule associated with profound deafness and loss of vestibular function occurs frequently as a sequella of bacterial meningitis and subsequent purulent labyrinthitis. Experimentally, in Streptococcus pneumoniae meningitis, it has been shown that a vigorous inflammatory ...
A H, Yeung, S P, Tinling, H A, Brodie
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Chronic cochlear de-efferentation and susceptibility to permanent acoustic injury
Hearing Research, 1995The question of whether olivocochlear (OC) efferent feedback can decrease permanent damage from acoustic overexposure was investigated by comparing the chronic threshold shifts and cochlear histopathology in guinea pigs either surgically de-efferented or sham-operated and then exposed (awake and unrestrained) to a 109- or 112-dB narrow-band noise ...
M C, Liberman, W Y, Gao
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Involvement of TNF-α and IFN-γ in Inflammation-Mediated Cochlear Injury
Annals of Otology, Rhinology & Laryngology, 2019Objectives: Inflammation is crucial for the pathogenesis of acquired sensorineural hearing loss, but the precise mechanism involved remains elusive. Among a number of inflammatory mediators, tumor necrosis factor-alpha (TNF-α) plays a pivotal role in cisplatin ototoxicity.
Sung K. Moon, Jeong-Im Woo, David J. Lim
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Cochlear nerve injuries caused by cerebellopontine angle manipulations
Journal of Neurosurgery, 1987✓ Changes in the response from the cochlear nerve in dogs resulting from cerebellopontine angle (CPA) manipulations were correlated with histological changes in the nerve. The aim of this study was to determine the mechanisms underlying hearing deficits incurred as a result of manipulations in the CPA.
T, Sekiya, A R, Møller
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The Healing Of The External Cochlear Wall In The Guinea Pig After Mechanical Injury
Acta Oto-Laryngologica, 1973The bony and vascular repair process of the cochlea was studied after mechanical lesions on the external cochlear wall in the guinea pig. Bony healing of the bulla and the cochlear wall occurred surprisingly rapidly. Intracochlear hemorrhage appeared to be controlled by reflex closure of the supplying vessels.
A, Axelsson, O, Hallén
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Ionic changes in cochlear endolymph of the guinea pig induced by acoustic injury
Hearing Research, 1988The effects of acoustic overstimulation on the endocochlear potential (EP) and on concentrations of ions (K+, Na+, Cl-, H+, HCO3-, and Ca2+) in endolymph were investigated using ion-selective microelectrodes. A slight but significant elevation of the EP and alkalinization of the endolymph were induced by acoustic overstimulation, whereas there was ...
K, Ikeda, J, Kusakari, T, Takasaka
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Ferroptosis contributes to lead-induced cochlear spiral ganglion neurons injury
ToxicologyThe underlying mechanisms of lead exposure-induced cochlear spiral ganglion neurons (SGNs) injury are not yet clear. This study explored whether ferroptosis is involved in lead-induced SGNs injury and investigated the mechanism of lead-induced iron overload in SGNs. A primary culture cell model of lead acetate-induced SGNs damage was established.
Huping, Huang +11 more
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