Results 111 to 120 of about 2,256,617 (260)

Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Cockayne syndrome group B (CSB) belongs to the SWI2/SNF2 family chromatin remodelers and plays critical roles in DNA damage response, repair, and gene expression.
Jun Xu, Wei Wang, Liang Xu, Jia-Yu Chen, J. Chong, Juntaek Oh, A. Leschziner, Xiang-Dong Fu, Dong Wang   +8 more
semanticscholar   +1 more source

Free Radicals in Health and Disease

MedComm, Volume 6, Issue 10, October 2025.
Free radicals have dual roles that can either selectively create oxidative damages to transformed cells in treating proliferative diseases such as cancers and some dermatological disorders or boost the antioxidant system in treating degenerative diseases such as neurodegenerative disorder, joint degeneration, and metabolic conditions.
Xiaofeng Dai, Zizheng Huang, Ruohan Lyu
wiley   +1 more source

Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction

Protein & Cell, 2019
Cockayne syndrome (CS) is a rare autosomal recessive inherited disorder characterized by a variety of clinical features, including increased sensitivity to sunlight, progressive neurological abnormalities, and the appearance of premature aging.
Si Wang, Zheying Min, Qianzhao Ji, Lingling Geng, Yao Su, Zunpeng Liu, Huifang Hu, Lixia Wang, Weiqi Zhang, Keiichiro Suzuiki, Yu Huang, Puyao Zhang, T. Tang, J. Qu, Yang Yu, Guang-Hui Liu, J. Qiao   +16 more
semanticscholar   +1 more source

Oxygen-Dependent Accumulation of Purine DNA Lesions in Cockayne Syndrome Cells

Cells, 2020
Cockayne Syndrome (CS) is an autosomal recessive neurodegenerative premature aging disorder associated with defects in nucleotide excision repair (NER).
M. Krokidis, M. D'errico, B. Pascucci, E. Parlanti, A. Masi, C. Ferreri, C. Chatgilialoglu   +6 more
semanticscholar   +1 more source

Dynamic Interplay between Cockayne Syndrome Protein B and Poly(ADP-Ribose) Polymerase 1 during Oxidative DNA Damage Repair [PDF]

, 2022
Robert J. Lake, Rabeya Bilkis, Hua-Ying Fan   +2 more
openalex   +1 more source

Transcription‐coupled repair: tangled up in convoluted repair

The FEBS Journal, Volume 292, Issue 20, Page 5288-5323, October 2025.
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher, Yun Jin Pai, Alex Pines, Wim Vermeulen   +3 more
wiley   +1 more source

Identification of reproduction-related gene polymorphisms using whole transcriptome sequencing in the Large White pig population [PDF]

, 2015
201
Fischer, Daniel, Gyenesei, Attila, Laiho, Asta, Sironen, Anu   +3 more
core   +1 more source

A Practical Guide to Genetic Eye Conditions for Paediatricians

Journal of Paediatrics and Child Health, Volume 61, Issue 10, Page 1538-1548, October 2025.
ABSTRACT Introduction Inherited eye disorders, though individually rare, are a collectively common cause of paediatric vision impairment. Many occur as part of a syndrome, in association with congenital anomalies and/or growth/developmental disorders.
Richard Lin, Alan Ma, Benjamin M. Nash, Zachary McPherson, John R. Grigg, Robyn V. Jamieson   +5 more
wiley   +1 more source

Defective transcription of ATF3 responsive genes, a marker for Cockayne Syndrome

Scientific Reports, 2020
Cockayne syndrome (CS) is a rare genetic disorder caused by mutations (dysfunction) in CSA and CSB. CS patients exhibit mild photosensitivity and severe neurological problems.
A. Epanchintsev, Marc-Alexander Rauschendorf, Federico Costanzo, N. Calmels, C. Obringer, A. Sarasin, F. Coin, V. Laugel, J. Egly   +8 more
semanticscholar   +1 more source

The Cockayne syndrome group A and B proteins are part of a ubiquitin–proteasome degradation complex regulating cell division

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Here, we demonstrate that CSA and CSB proteins, primarily defined as DNA repair factors, are part of a ubiquitin/proteasome degradation process during cytokinesis.
E. Paccosi, Federico Costanzo, Michele Costantino, Alessio Balzerano, Laura Monteonofrio, S. Soddu, G. Prantera, S. Brancorsini, J. Egly, Luca Proietti-De-Santis   +9 more
semanticscholar   +1 more source