Results 121 to 130 of about 2,256,617 (260)

Epigenetic Regulation of Aging and its Rejuvenation

MedComm, Volume 6, Issue 9, September 2025.
This article provides an overview of the epigenetic mechanisms and key targets involved in aging, including DNA methylation, histone modifications, chromatin remodeling, and changes in noncoding RNAs. It also introduces various intervention strategies aimed at reversing epigenetic changes to delay aging and treat diseases.
Yongpan An, Qian Wang, Ke Gao, Chi Zhang, Yanan Ouyang, Ruixiao Li, Zhou Ma, Tong Wu, Lifan Zhou, Zhengwei Xie, Rui Zhang, Guojun Wu   +11 more
wiley   +1 more source

Embedding Pharmacogenetics Into Clinical Practice to Improve Patient Outcomes

Annals of Human Genetics, Volume 89, Issue 5, Page 398-405, September 2025.
ABSTRACT Pharmacogenomics, the use of germline genomic data to guide prescription to improve effective and safer medication, holds promise as a clinical intervention. To date in most health systems, there has been limited uptake of pharmacogenomic testing confined to a few single drug–gene associations.
John Henry McDermott, Videha Sharma, Jessica Keen, William Gerard Newman   +3 more
wiley   +1 more source

Xeroderma pigmentosum group A protein loads as a separate factor onto DNA lesions [PDF]

, 2003
Nucleotide excision repair (NER) is the main DNA repair pathway in mammals for removal of UV-induced lesions. NER involves the concerted action of more than 25 polypeptides in a coordinated fashion.
Hoeijmakers, J.H.J. (Jan), Hoogstraten, D. (Deborah), Houtsmuller, A.B. (Adriaan), Mone, M.J., Nigg, A.L. (Alex), Rademakers, S. (Suzanne), Vermeulen, W. (Wim), Volker, M. (Marcel), Zeeland, A.A. (Albert) van   +8 more
core   +4 more sources

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, Volume 12, Issue 31, August 21, 2025.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Hypomorphic PCNA mutation underlies a novel human DNA repair disorder [PDF]

, 2014
A number of human disorders, including Cockayne syndrome, UV-sensitive syndrome, xeroderma pigmentosum and trichothiodystrophy, result from the mutation of genes encoding molecules important for nucleotide excision repair.
Baple, Emma L, Chambers, Helen, Chioza, Barry A, Coblentz, Roselyn, Crosby, Andrew H, Cross, Harold E, Fawcett, Heather, Green, Catherine M, Harlalka, Gaurav V, Jackson, Andrew P, Last, James I, Lehmann, Alan R, Mansour, Sahar, Muggenthaler, Martina, Nakazawa, Yuka, Ogi, Tomoo, Patton, Michael A, Rich, Phillip, Sreekantan-Nair, Ajith, Stein, Constance K, Taylor, A Malcolm R, Wagner, Karin   +21 more
core  

TFIIH: a key component in multiple DNA transactions [PDF]

, 1996
The transcription factor TFIIH is a versatile, multi-functional protein complex with multiple engagements. Apart from its role in basal transcription, TFIIH is intimately implicated in DNA repair and (probably) in cell cycle control (both of which are ...
Abouseekhra, Akoulitchev, Bailis, Bardwell, Bardwell, Broughton, Broughton, Chen, Ciamowsk, Clarke, Cleaver, Conaway, Dahmus, Devault, Donahue, Drapkin, Feaver, Feaver, Fisher, Frederick, Gerber, Goodrich, Gulyas, Guzder, Hanawak, Henning, Hildebrandt, Hoeijmakers, Holstage, Humbert, Itin, Jackson, Kim, Kleijer, Koleske, Kozhina, Lehmann, Liao, Maldonado, Matsui, Montelone, Mu, Nance, Nigg, O'Donovan, Ossipow, Parvin, Roy, Roy, Schaeffer, Schaeffer, Schiestl, Serizawa, Serizawa, Shiekhattar, Studitsky, Sung, Svejstrup, Tassan, Thompson, Troelstra, Usheva, Valay, Van Vuuren, Vermeulen, Vermeulen, Wang, Wang, Yoon, Zawel   +69 more
core   +1 more source

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

Aging Cell, Volume 24, Issue 8, August 2025.
Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji, Hisaya Kato, Masaya Koshizaka, Hiyori Kaneko, Yusuke Baba, Takahiro Ishikawa, Naoya Teramoto, Daisuke Kinoshita, Ayano Yamaguchi, Yukari Maeda, Yosuke Inaba, Yuki Shiko, Yoshihito Ozawa, Vilhelm A. Bohr, Yoshiro Maezawa, Koutaro Yokote   +15 more
wiley   +1 more source

Cockayne Syndrome : A Report Of Two Siblings In A Family

Indian Journal of Dermatology, 2001
Family cases of cockayne’s syndrome are very rare. We report tow siblings in a family affected with this syndrome and highlight the significance of cutaneous features of this syndrome.
Thappa D.M, Kumar R.H, Nadrajan S, Elangovan S   +3 more
doaj  

Neonatal onset Cockayne syndrome: A rare photogenodermatosis

Indian Journal of Paediatric Dermatology, 2016
Cockayne syndrome (CS) is a rare genodermatosis with autosomal recessive inheritance and around 180 cases have been reported worldwide. It results from mutation in genes ERCC8 and ERCC6 coding for proteins involved in transcription-coupled repair.
A L Senthil Kumar, C Aruna, K Swapna, D Ramamurthy   +3 more
doaj   +1 more source

The Cockayne syndrome B protein, involved in transcription-coupled DNA repair, resides in an RNA polymerase II-containing complex [PDF]

, 1997
Transcription-coupled repair (TCR), a subpathway of nucleotide excision repair (NER) defective in Cockayne syndrome A and B (CSA and CSB), is responsible for the preferential removal of DNA lesions from the transcribed strand of active genes, permitting ...
Bootsma, D. (Dirk), Citterio, E. (Elisabetta), Constantinou, A., Egly, J-M. (Jean-Marc), Gool, A.J. (Alain) van, Hoeijmakers, J.H.J. (Jan), Os, R.I. (Roselinde) van, Rademakers, S. (Suzanne), Vermeulen, W. (Wim)   +8 more
core   +2 more sources