Results 151 to 160 of about 195,547 (311)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 1988 cod 2 nCod tongues have always been a source of employment and summer pocket money for the younger set in Newfoundland, and youngsters can still be seen today in any Newfoundland fishing community cutting out tongues, where fishermen are ...
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Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Modeling and Optimization of Transition Metal-Catalyzed Peracetic Acid Oxidation for Advanced Polishing of Biologically Treated Leachate. [PDF]
ACS OmegaÜnal E +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
, 1988 cod 2 nWe are concerned about the situation with the 2J3KL cod stocks. WJK's joke.PRINTED ITEM DNE Sup [But maybe useful in _defining_]FEB 17 1988 [check] WKG.M.StoryUsed I and SupNot UsedNot Usedcodd,codde,cod-fish,FISH n,BANK,RED,ROCK,SHORE1,TOM ...
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A Persistent Ni(0)-Pentalene Complex with High Fluxionality: Does Stronger Antiaromaticity Promote Metal-Ligand Interactions? [PDF]
J Am Chem SocKuwata R +9 more
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 1978 cod 2 n...With incredible quantities, and no lesse varietie of kindes of fish in the sea and fresh waters, as Trouts, Salmons and..also Cod, which alone draweth many nations thither, and is become the most famous fishing of the world.PRINTED ITEM
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