Results 111 to 120 of about 30,579 (293)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Supplement 1. SAS program code to estimate regression slopes and then test equivalence, and Ambystoma data. [PDF]

open access: yes, 2016
File List EquivSlope.sas -- EquivSlope.sas: SAS (SAS 1999) program code to estimate regression slopes, assuming ar(1) errors, then test equivalence. Ambystoma.txt -- Ambystoma data set.
Philip M. Dixon (713102)   +1 more
core   +1 more source

On the equivalence of codes and codes with an automorphism having two cycles

open access: yesDiscrete Mathematics, 1990
This paper presents results giving sufficient conditions under which two codes are equivalent. This technique has been applied to certain binary quasicyclic codes. Self-dual codes of length 2r or \(2r+2\) over arbitrary fields having an automorphism of prime order r have also been examined. This study has further been used to construct and to count the
openaire   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

open access: yesFEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Two Scales, One Methodology - Expenditure Based Equivalence Scales for the United States and Germany [PDF]

open access: yes
Choosing an appropriate equivalence scale is a prerequisite for comparisons of economic wellbeing income distribution, inequality or poverty. This is true for country specific work or for cross-national comparisons.
Joachim Merz   +4 more
core  

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Weak Instances of the Inverse Matrix Code Equivalence Problem [PDF]

open access: yes
Nowadays, the Matrix Code Equivalence Problem shows potential applicability in constructing efficient and secure advanced digital signatures, focusing on linkable ring signatures, threshold signatures, and blind signatures. Current constructions of these
Jesús-Javier Chi-Domínguez
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Proving Termination via Measure Transfer in Equivalence Checking [PDF]

open access: yes
Program verification can benefit from proofs with varied induction schemas. A natural class of induction schemas, functional induction, consists of those derived from definitions of functions.
Kunčak, Viktor   +3 more
core  

Home - About - Disclaimer - Privacy