Results 131 to 140 of about 4,499,855 (300)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
cellmlmanip and chaste_codegen: automatic CellML to C++ code generation with fixes for singularities and automatically generated Jacobians. [PDF]
Wellcome Open Res, 2021 Hendrix M +6 more
europepmc +1 more source
Code Generation from UML Model: State of the Art and Practical Implications
The paper draws attention to the problem of code generation under advanced software development. In their previous publications the authors already discussed several issues associated with the inconsistency between the generated software components and ...
Sējāns, Jānis +2 more
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Lowcomote: Training the Next Generation of Experts in Scalable Low-Code Engineering Platforms
, 2019 International audienceLow-Code Development Platforms (LCDPs) are software development platforms on the Cloud, provided through a Platform-as-a-Service model, which allow users to build completely operational applications by interacting through dynamic ...
Kolovos, Dimitrios, S. +7 more
core +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Alaska Criminal Code Revision — Tentative Draft, Part 2: General Principles of Criminal Liability; Parties to a Crime; Attempt; Solicitation; Justification; Robbery; Bribery; Perjury [PDF]
, 1977 As of 1975, Alaska’s criminal laws were based primarily on Oregon criminal statutes as they existed at the close of the nineteenth century, with new statutes added and old statutes amended over the succeeding 75 years by Alaska territorial and state ...
Alaska Criminal Code Revision Subcommission
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, 2022 Generation R onderzoekt de groei, ontwikkeling en gezondheid van 10.000 opgroeiende kinderen in Rotterdam (prospective cohort study). Deze kinderen worden al gevolgd vanaf de vroege zwangerschap en blijven we volgen tot hun jong volwassenheid.
Erasmus MC, afdeling Generation R
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An Empirical Study of the Code Generation of Safety-Critical Software Using LLMs
Applied SciencesIn the digital era of increasing software complexity, improving the development efficiency of safety-critical software is a challenging task faced by academia and industry in domains such as nuclear energy, aviation, the automotive industry, and rail ...
Mingxing Liu +5 more
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Applied SciencesConstraint satisfaction problems (CSPs) are widely used in domains such as product configuration, scheduling, and resource allocation. However, formulating constraint models remains a significant challenge that often requires specialized expertise in ...
Roberto Penco +3 more
doaj +1 more source