Results 131 to 140 of about 461,576 (313)
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Performance Evaluation of Large Language Models for High-Performance Code Generation: A Multi-Agent Approach (MARCO) [PDF]
Large language models (LLMs) have transformed software development through code generation capabilities, yet their effectiveness for high-performance computing (HPC) remains limited.
Cooney, Denise +9 more
core +1 more source
Semantic composition of robotic solver algorithms on graph structures
Frontiers in Robotics and AIThis article introduces a model-based design, implementation, deployment, and execution methodology, with tools supporting the systematic composition of algorithms from generic and domain-specific computational building blocks that prevent code ...
Sven Schneider +5 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A Bibliometric Exposition and Review on Leveraging LLMs for Programming Education
IEEE AccessThe world is experiencing an AI revolution, with large language models (LLMs) transforming various industries, including education. Academics are striving to harness the potential of LLMs while also contending with their risks.
Joanah Pwanedo Amos +7 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Native Code Generation Using the Transterpreter [PDF]
, 2006 We are interested in languages that provide powerful abstractions for concurrency and parallelism that execute everywhere, efficiently. Currently, the existing runtime environments for the occam-pi programming language provide either one of these ...
Jacobsen, Christian L. +2 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
PyRates-A code-generation tool for modeling dynamical systems in biology and beyond. [PDF]
PLoS Comput Biol, 2023 Gast R, Knösche TR, Kennedy A.
europepmc +1 more source