Results 141 to 150 of about 461,576 (313)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Navigating the Pitfalls: Analyzing the Behavior of LLMs as a Coding Assistant for Computer Science Students—A Systematic Review of the Literature

IEEE Access
In recent years, large language models (LLMs) have been employed significantly in different domains of computing education. Nevertheless, these models have been focused on essential adherence to their integration as coding assistants in computing ...
Farman Ali Pirzado, Awais Ahmed, Roman Alejandro Mendoza-Urdiales, Hugo Terashima-Marin   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Target code generation from G-machine code [PDF]

, 1986
The G-machine is a stack machine for von-Neumann-like execution of lazy functional languages, using graph reduction. This paper describes how target code generation from G-machine code is performed in a compiler for Lazy ML.
Thomas Johnsson
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

An Empirical Study of the Code Generation of Safety-Critical Software Using LLMs

Applied Sciences
In the digital era of increasing software complexity, improving the development efficiency of safety-critical software is a challenging task faced by academia and industry in domains such as nuclear energy, aviation, the automotive industry, and rail ...
Mingxing Liu, Junfeng Wang, Tao Lin, Quan Ma, Zhiyang Fang, Yanqun Wu   +5 more
doaj   +1 more source

RateML: A Code Generation Tool for Brain Network Models. [PDF]

Front Netw Physiol, 2022
van der Vlag M, Woodman M, Fousek J, Diaz-Pier S, Pérez Martín A, Jirsa V, Morrison A.   +6 more
europepmc   +1 more source

The Correctness of an Optimized Code Generation

DAIMI Report Series, 1992
<p>For a functional programming language with a lazy standard semantics, we define a strictness analysis by means of abstract interpretation. Using the information from the strictness analysis we are able to define a code generation which avoids delaying the evaluation of the argument to an application, provided that the corresponding function is
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Automatic generation of code [PDF]

, 2006
Bakalaura darbā tiek apskatīta programmēšanas automatizācija, izmantojot koda ģeneratorus. Galvenais uzsvars tiek likts uz tīmekļa risinājumu ģenerēšanu.
Krūze, Ēriks
core