Results 131 to 140 of about 3,948 (253)

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

open access: yesAdvanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang   +10 more
wiley   +1 more source

Uma análise da relação entre code smells e dívida técnica auto-admitida

open access: gold, 2019
Felipe Gustavo de S. Gomes   +4 more
openalex   +2 more sources

IgG‐Bridging–Seeded Synergistic Aggregation of SARS‐CoV‐2 Spikes Underlies Potent Neutralization by a Low‐Affinity Antibody

open access: yesAdvanced Science, EarlyView.
Low‐affinity antibodies are frequently disregarded in discovery pipelines. This work reports P5‐1C8, a Class 1 SARS‐CoV‐2 antibody with weak trimer binding (KD‐to‐IC50 > 3700‐fold) yet potent neutralization of Omicron JN.1. Structural, biophysical, functional, and coarse‐grained simulations collectively demonstrate that transient inter‐spike IgG ...
Niannian Lv   +29 more
wiley   +1 more source

Cryo‐EM Structures Reveal the Molecular Basis of Asymmetric Allosteric Activation by MMOB in the Hydroxylase of Soluble Methane Monooxygenase

open access: yesAdvanced Science, EarlyView.
Cryo‐EM analysis reveals an asymmetric MMOH–MMOB complex with distinct protomers, where MMOB binding triggers structural rearrangements from the surface to the active site. This conformational asymmetry shortens the Fe···Fe distance to 2.7 Å in one protomer, forming a geometry suitable for O2 activation and supporting a sequential catalytic mechanism ...
Yunha Hwang   +9 more
wiley   +1 more source

Multi-label code-smell dataset

open access: gold, 2023
Binh Nguyen Thanh
openalex   +1 more source

Modulus Matching and Interface Enhancement: A Synergistic Strategy for Antidelamination High‐Performance Stretchable Triboelectric Nanogenerator

open access: yesAdvanced Science, EarlyView.
A bioinspired TENG features a homologously paired interface with matched modulus. Ultrasonic cavitation enhances its toughness to 190 N m−1 (3.2× higher), preventing delamination under 400% strain. Abstract With the growing demand for flexible self‐powered energy sources for wearable bioelectronics, triboelectric nanogenerator (TENG) have emerged as a ...
Shiwei Xu   +7 more
wiley   +1 more source

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