Results 211 to 220 of about 1,546,262 (243)

Tezepelumab in Chinese Patients With Severe Chronic Rhinosinusitis With Nasal Polyps: A Prespecified Subgroup Analysis of the Phase 3 WAYPOINT Trial

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) in Chinese patients often exhibits a mixed Type 1/2/3 inflammatory phenotype (63%), potentially impacting the efficacy of biologics targeting Type 2 inflammation. This prespecified subgroup analysis of WAYPOINT (NCT04851964) evaluated the efficacy and safety of tezepelumab in Chinese
Li Hu, Houyong Li, Xicai Sun, Quan Liu, Yu Xu, Jiangang Fan, Andrew Foster, Claudia Chen, Yun Chon, Dehui Wang   +9 more
wiley   +1 more source

Spending time in a forest vs. a virtual forest simulation: qualitative and quantitative effects on stress perception and psychological wellbeing in a randomized cross-over trial of highly sensitive persons. [PDF]

Front Psychol
Kühn J, Lederer AK, Sättele C, Huber R, Oomen-Welke K.   +4 more
europepmc   +1 more source

Functional Specialization of Respiratory and Olfactory Mucus Revealed by Proteomic Profiling

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Mucus overlies the nasal mucosa in the respiratory and olfactory regions, which perform distinct physiological functions. However, proteomic differences between respiratory mucosa (RM) and olfactory cleft (OC) mucus remain unclear.
Anna Kristina Hernandez, Karoline Lantzsch, Romain Topalian, Nadine Gunder, Philipp Hubel, Katharina Schindowski, Jens Pfannstiel, Thomas Hummel   +7 more
wiley   +1 more source

Rhinology Fellowship Training in the United States: Insights From a National Survey

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background The proportion of otolaryngology trainees pursuing fellowship has increased alongside rapid expansion in rhinology fellowship programs. Contemporary data evaluating trainee motivations, expectations, and outcomes remain limited. This study assesses contemporary data evaluating trainee motivations, expectations, and outcomes among US
Daniel B. Spielman, Jacob Rosenstadt, Hemali Shah, Joshua M. Levy, Carol Yan, Tran Locke, Tyler Merril, Nicholas R. Rowan   +7 more
wiley   +1 more source

Complete Pathway Refactoring and Combinatorial Biosynthesis of Anthracyclines for Modulation of Histone Eviction and DNA Damage Bioactivities

Angewandte Chemie, EarlyView.
A synthetic biology platform was established for the complete refactoring of complex anthracycline biosynthetic pathways in Streptomyces coelicolor using standardized, chemically synthetic DNA parts. This modular construction enabled streamlined combinatorial biosynthesis, yielding novel analogs that decouple DNA damage from chromatin damage (histone ...
Rongbin Wang, Heli Tirkkonen, Sabina Y. van der Zanden, Larissa Ponomareva, Isaline Fagon, Leslie Fève, Kendall Paige, Courtney L. Brown, Nora Schwartz, Jacob Hecht, Jennifer Nguyen, Jon S. Thorson, Jacques Neefjes, S. Eric Nybo, Khaled A. Shaaban, Mikko Metsä‐Ketelä   +15 more
wiley   +1 more source

Gastrointestinal symptoms correlate with core clinical features and systemic inflammation in myalgic encephalomyelitis/chronic fatigue syndrome. [PDF]

J Transl Med
Brown M, Vernon SD, Indart AC, Green PH, Alaedini A.   +4 more
europepmc   +1 more source

31P Solid‐State NMR‐Enabled Development of a Pt/Aluminum Tripolyphosphate Catalyst for Selective C─O Bond Hydrogenolysis of Phenols

Angewandte Chemie, EarlyView.
31P solid‐state nuclear magnetic resonance analysis revealed the presence of aluminum tripolyphosphate on the surface of a platinum/aluminum condensed phosphate mixture (ACPM) catalyst. This finding led to the development of a Pt/aluminum tripolyphosphate (Pt/ATPP) catalyst for the selective hydrogenolysis of phenols to arenes.
Kento Oshida, Akito Ai, Shinji Tanaka, Yuichiro Okuzumi, Yuga Ezoe, Takeyuki Nogami, Rin Seki, Hiroki Miura, Tetsuya Shishido, Akira Nakayama, Xiongjie Jin, Kyoko Nozaki   +11 more
wiley   +1 more source

Sensing Sociality: Disruptions of Social Life When Living With Chemosensory Dysfunctions After COVID-19. [PDF]

Qual Health Res
Neuman N, Lövestam E, Karlén J, Sandvik P.   +3 more
europepmc   +1 more source

Guidance for protocol content and reporting of dog-assisted interventions in randomised controlled trials: explanation and elaboration of the SPIRIT 2025 and CONSORT 2025 extensions. [PDF]

BMC Med Res Methodol
Shoesmith E, Ratschen E, Riga E, Mills DS, Gibsone S, McMillan D, Wu Q, Clarke C, Sprange K, Meints K, Gee NR, Nieforth LO, Dollion N, Fine A, Hall SS.   +14 more
europepmc   +1 more source

Software technical debt prediction based on complex software networks. [PDF]

PLoS One
Jiang B, Cen J, Zhu E, Wang J.
europepmc   +1 more source