Results 41 to 50 of about 1,546,262 (243)
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Code Smell Detection Using Ensemble Machine Learning Algorithms
Applied Sciences, 2022 Code smells are the result of not following software engineering principles during software development, especially in the design and coding phase. It leads to low maintainability.
Seema Dewangan +3 more
doaj +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Definition, implementation and validation of energy code smells: an exploratory study on an embedded system [PDF]
, 2013 Optimizing software in terms of energy efficiency is one of the challenges that both research and industry will have to face in the next few years.We consider energy efficiency as a software product quality characteristic, to be improved through the ...
Ardito, Luca +8 more
core
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Exploring the Relationship between Test Smells and Code Smells
Background: In software evolution, code smells and test smells represent design f laws that can negatively impact the maintainability, readability, and reliability of both production and test code.
Sandeep Reddy, Munagala +1 more
core +3 more sources
Exploring the Connection between the TDD Practice and Test Smells—A Systematic Literature Review
ComputersTest-driven development (TDD) is an agile practice of writing test code before production code, following three stages: red, green, and refactor. In the red stage, the test code is written; in the green stage, the minimum code necessary to make the test ...
Matheus Marabesi +2 more
doaj +1 more source
IEEE Access, 2023 The quality of software systems may be seriously impacted by specific types of source code anomalies. For example, poor programming practices result in Code Smells (CSs), which are a specific type of source code anomalies.
Ivian L. Castellano +6 more
doaj +1 more source