Results 61 to 70 of about 916,424 (298)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Codes of conduct should help scientists navigate societal expectations
Humanities & Social Sciences CommunicationsScientists are increasingly expected to incorporate socio-political considerations in their work, for instance by anticipating potential socio-political ramifications.
Jacopo Ambrosj +2 more
doaj +1 more source
Workplace Code of Conduct [PDF]
, 2005 Codes of conduct designed by the Fair Labor Association and accepted for implementation by companies that are members of the coalition represented by the ...
Fair Labor Association
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Corporate Social Responsibility Standards: Is it Possible to Meet Diverse Customer Requirements?
Management Systems in Production Engineering, 2022 The purpose of the study is to review the internationally recognised CSR (Corporate Social Responsibility) standards, codes of conduct (cross-industry and industry-specific used in electronics, automotive and steel industry) and selected codes and ...
Sütőová Andrea, Kóča Ferdinand
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Journal of Contemporary Urban Affairs, 2017 This article studies the process of professionalization in general and particularly in architecture and reviews the concept of professional ethics and the codes and documents related to it.
Hossein Sadri
doaj +1 more source
Codes and Virtues: Can Good Lawyers be Good Ethical Deliberators? [PDF]
, 1996 Regardless of its specific contents, any black letter statutory codification regulating lawyers\u27 conduct will be flawed as an instrument of ethics for lawyers. This is the central thesis of this Article.
Feldman, Heidi Li
core +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source