Results 61 to 70 of about 166,457 (253)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Speaking Freely vs. Dignitary Harm: Balancing Students’ Freedom of Expression and Associational Rights with their Right to an Equitable Learning Environment

open access: yesAtlantis, 2020
In this article, I examine the difficulty of using student codes of conduct and civility policies as a way to restrict harmful speech. I argue that policies used to monitor students’ non-academic behaviour provide administrators with a means to restrict
Elizabeth Brulé
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Value pluralism in research integrity

open access: yesResearch Integrity and Peer Review, 2019
Both scientists and society at large have rightfully become increasingly concerned about research integrity in recent decades. In response, codes of conduct for research have been developed and elaborated.
Rik Peels   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

VALUE CREATION THROUGH CORPORATE GOVERNANCE [PDF]

open access: yesCES Working Papers, 2013
Companies spend time and money in order to improve their corporate governance (CG) system and also do not forget to inform third parties about their efforts in this field.
Elena Chitimus
doaj  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Tatar folklore as a basis for the folk etiquette (late 19th – early 20th centuries)

open access: yesИсторическая этнология, 2017
The etiquette of many Turkic peoples has common features. For example, the cult of the elders, the tradition of hospitality. However, every historical epoch creates its own norms of behavior.
Liliya R. Gabdrafikova
doaj  

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