Results 71 to 80 of about 4,070,895 (341)

CodeFusion: A Pre-trained Diffusion Model for Code Generation [PDF]

, 2023
Mukul Singh, José Cambronero, Sumit Gulwani, Vu Le, Carina Negreanu, Gust Verbruggen   +5 more
openalex   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Editorial: Big code, little code, open code, old code

Code4Lib Journal, 2023
Paraphrasing the title of Christine L. Borgman’s inaugural lecture in Göttingen some years ago “Big data, little data, open data” I could say that the current issue of Code4Lib is about big code, little code, open code, old code. The good side of coding is that effective contribution could be done with different levels and types of background knowledge.
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Layer codes

Nature Communications
80 pages, 33 figures; v2 substantial changes to improve ...
Dominic J. Williamson, Nouédyn Baspin
openaire   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

One health assessment of farmers’ knowledge, attitudes, and practices (KAPs) on zoonoses in Bangladesh

Scientific Reports
In Bangladesh, farming serves as a key livelihood, leading to a higher risk of zoonotic diseases due to frequent animal interactions and traditional practices.
Md Jisan Ahmed, Md Ismile Hossain Bhuiyan, Ritu Chalise, Mustakim Mamun, Prajwal Bhandari, Khairul Islam, Shahrin Sultana Jami, Mahabbat Ali, Mirza Synthia Sabrin   +8 more
doaj   +1 more source

Blind Index Coding

, 2015
We introduce the blind index coding (BIC) problem, in which a single sender communicates distinct messages to multiple users over a shared channel. Each user has partial knowledge of each message as side information. However, unlike classic index coding,
Avestimehr, A. Salman, Kao, David T. H., Maddah-Ali, Mohammad Ali   +2 more
core   +1 more source

Sequential adaptive design for emulating costly computer codes [PDF]

, 2022
Hossein Mohammadi, Peter Challenor
openalex   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source