Results 61 to 70 of about 7,506,861 (344)
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Identification of protein coding regions in RNA transcripts [PDF]
Proceedings of the 5th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics, 2014 Massive parallel sequencing of RNA transcripts by next-generation technology (RNA-Seq) generates critically important data for eukaryotic gene discovery. Gene finding in transcripts can be done by statistical (alignment-free) as well as by alignment-based methods.
Shiyuyun Tang +2 more
openaire +5 more sources
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source
Peran Coding dan Non-Coding Region dari Gen Polimerase Kompleks Dalam Adaptasi Virus Avian Influenza
Buletin Veteriner Udayana, 2012 Avian influenza (AI) is an avian diseases that can cause deadly humaninfection. The disease is caused by Orthomyxoviridae virus, genus influenzavirus type A,subtype H5N1.
Gusti Ayu Yuniati Kencana
doaj
The complete mitochondrial genome of the jewel beetle Trachys variolaris (Coleoptera: Buprestidae)
Mitochondrial DNA. Part B. Resources, 2019 The complete mitochondrial genome (mitogenome) of the jewel beetle, Trachys variolaris, was sequenced and described. The mitogenome of T. variolaris is a typical circular DNA molecule with 16,771 bp in length.
Liangming Cao, Xiaoyi Wang
doaj +1 more source
m6A in mRNA coding regions promotes translation via the RNA helicase-containing YTHDC2
Nature Communications, 2019 Dynamic mRNA modification in the form of N6-methyladenosine (m6A) adds considerable richness and sophistication to gene regulation. The m6A mark is asymmetrically distributed along mature mRNAs, with approximately 35% of m6A residues located within the ...
Yuanhui Mao +6 more
semanticscholar +1 more source
Analysis of thePTCH coding region in human rhabdomyosarcoma [PDF]
Human Mutation, 2002 Inherited mutations of the human tumor suppressor gene Patched (PTCH) lead to an autosomal dominant disorder known as Nevoid Basal Cell Carcinoma Syndrome (NBCCS). The syndrome is characterized by a combination of developmental abnormalities and a predisposition to tumor formation.
Axel Walch +7 more
openaire +5 more sources
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
A map of constrained coding regions in the human genome [PDF]
Nature Genetics, 2017 ABSTRACTDeep catalogs of genetic variation collected from many thousands of humans enable the detection of intraspecies constraint by revealing coding regions with a scarcity of variation. While existing techniques summarize constraint for entire genes, single metrics cannot capture the fine-scale variability in constraint within each protein-coding ...
James M. Havrilla +3 more
openaire +5 more sources