Results 121 to 130 of about 1,514,462 (352)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

GROUNDED THEORY AND SOCIAL-PEDAGOGICAL RESEARCH

open access: yesИстраживања, 2013
Debates on the application of the quantitative, qualitative or mixed methodological ap­proaches in social sciences are mainly driven by the need to justify meaning and scope of qualitative research in the context of modern science. In this sense, the aim
Olivera Č. Knežević-Florić   +1 more
doaj  

Barriers to Research in the Humanities in Iran: a window to Science Policy

open access: yesIranian Journal of Information Processing & Management, 2021
Conducting research in humanities sciences in Iran is faces with different barriers, including the small number of researchers, financial resources shortage, weak research infrastructure, etc.
Behrooz Rasuli, Parviz Shahriari
doaj  

The Role of Imagination in Social Scientific Discovery: Why Machine Discoverers Will Need Imagination Algorithms [PDF]

open access: yes, 2019
When philosophers discuss the possibility of machines making scientific discoveries, they typically focus on discoveries in physics, biology, chemistry and mathematics.
Stuart, Michael
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Presentation of organizational culture model of elementary schools of alborz province

open access: yesمجله علوم روانشناختی, 2020
Background: Organizational culture plays a role in human behavior and is one of the most important concepts in behavioral sciences. But so far it has not been fully evaluated.
Maryam sasanian   +4 more
doaj  

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

A Meta-Analysis of Procedures to Change Implicit Measures [PDF]

open access: yes, 2019
Using a novel technique known as network meta-analysis, we synthesized evidence from 492 studies (87,418 participants) to investigate the effectiveness of procedures in changing implicit measures, which we define as response biases on implicit tasks.
Ast, Jordan R.   +6 more
core   +2 more sources

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