Results 121 to 130 of about 741,973 (309)

Open science and phenotyping in UK administrative health, education and social care data: the ECHILD phenotype code list repository

International Journal of Population Data Science
Administrative health data, such as the Hospital Episode Statistics (HES), can be used to identify groups of people with a particular target condition, a process known as phenotyping. Clinical phenotypes are useful as exposures, covariates and outcomes in research studies using administrative data, including health data linked to other sources such as ...
Jay, M.A., Lewis, K., Shi, D., Langella, R., Stone, T., Ní Chobhthaigh, S., Zylbersztejn, A., Blackburn, R., Harron, K.   +8 more
openaire   +4 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

BANOVA: An R Package for Hierarchical Bayesian ANOVA

Journal of Statistical Software, 2017
In this paper, we develop generalized hierarchical Bayesian ANOVA, to assist experimental researchers in the behavioral and social sciences in the analysis of experiments with within- and between-subjects factors.
Chen Dong, Michel Wedel
doaj   +1 more source

The Neurocognitive Process of Digital Radicalization: A Theoretical Model and Analytical Framework [PDF]

, 2019
Recent studies suggest that empathy induced by narrative messages can effectively facilitate persuasion and reduce psychological reactance. Although limited, emerging research on the etiology of radical political behavior has begun to explore the role of
Benning, Stephen D., Howard, Tiffiany, Poston, Brach   +2 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The parent-child relationship in the Colossians house code. A re reading from the social sciences

Ágora. Estudos Clássicos em Debate, 2021
Contrairement aux codes païens de la société gréco-romaine et hellénistique, l'auteur de la Lettre aux Colossiens définit la relation parent-enfant selon le point de vue d’un croyant. Le code domestique de Col 3, 20-21 examine les deux côtés de chacune des relations, montrant que l'obéissance des enfants aux parents est aussi importante que l'affection
openaire   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A study into the factors influencing the choice-making process of Indian students when selecting an international university for graduate studies using grounded theory [PDF]

, 2007
Paper presented at the conference in Amsterdam in the Netherlands, July 2007.Universities operate in an increasingly competitive market place facing new and complex socio-technical and economical challenges.
O'Brien, Ann, Page, Steve, Proctor, Tony, Webb, Paul   +3 more
core