Results 81 to 90 of about 1,098,453 (286)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Hierarchical complexity control algorithm for HEVC based on coding unit depth decision

open access: yesEURASIP Journal on Image and Video Processing, 2018
The next-generation High Efficiency Video Coding (HEVC) standard reduces the bit rate by 44% on average compared to the previous-generation H.264 standard, resulting in higher encoding complexity.
Fen Chen   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Precoding-Based Network Alignment For Three Unicast Sessions

open access: yes, 2014
We consider the problem of network coding across three unicast sessions over a directed acyclic graph, where each sender and the receiver is connected to the network via a single edge of unit capacity.
Das, Abhik Kumar   +5 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Spatio-temporal correlation based fast inter mode decision for HEVC

open access: yesTongxin xuebao, 2016
The new generation high efficiency video coding (HEVC) standard adopts coding tree unit (CTU) quadtree partition technology and ten inter prediction unit (PU) modes to improve compression efficiency significantly, but it brings in an enormous encoding ...
Wei ZHU   +3 more
doaj   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Acceleration for HEVC Encoder by Bimodal Segmentation of Rate-Distortion Cost and Accurate Determination of Early Termination and Early Split

open access: yesIEEE Access, 2019
The processing unit with a quad-tree structure in high efficiency video coding (HEVC/H.265) consists of a coding unit (CU), a prediction unit (PU), and a transform unit (TU). The CU and PU account for the majority of the computational complexity.
Kuang-Han Tai   +8 more
doaj   +1 more source

Source Coding with Fixed Lag Side Information

open access: yes, 2004
We consider source coding with fixed lag side information at the decoder. We focus on the special case of perfect side information with unit lag corresponding to source coding with feedforward (the dual of channel coding with feedback) introduced by ...
Martinian, Emin, Wornell, Gregory W.
core   +1 more source

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