Results 191 to 200 of about 494,112 (301)

A General Enzymatic Strategy for Site‐Specific Incorporation of Modified Genetic Building Blocks Into DNA

Advanced Science, EarlyView.
Eco‐friendly enzymatic synthesis of high‐fidelity, site‐specifically modified DNA using 3′‐blocked nucleotides for full synthetic control and next‐generation sequencing compatibility. ABSTRACT Methods for site‐specific incorporation of modified DNA building blocks remain limited.
Raveena Raveena, Bhavana Ramadas, Sidney Becker   +2 more
wiley   +1 more source

evo3D R package: a spatial haplotype framework for structure-informed analysis of molecular evolution. [PDF]

Mol Biol Evol
Broyles BK, He Q.
europepmc   +1 more source

Codon usage bias in animals: disentangling the effects of natural selection, effective population size and GC-biased gene conversion

bioRxiv, 2017
N. Galtier, C. Roux, M. Rousselle, J. Romiguier, E. Figuet, S. Glémin, N. Bierne, L. Duret   +7 more
semanticscholar   +1 more source

Epidermal METTL1‐Mediated m7G Modification Drives Psoriatic Inflammation by Stabilizing Bdkrb1 and Orchestrating Neutrophil Recruitment

Advanced Science, EarlyView.
This study unveils an unrecognized pro‐inflammatory epitranscriptomic checkpoint in psoriasis. By installing m7G modifications on the 5′ UTR of Bdkrb1 mRNA, METTL1 enhances receptor stability to orchestrate keratinocyte‐driven neutrophil recruitment via p38 MAPK signaling.
Chang Zhang, Jiayi Lu, Sihao Yan, Yirui Wang, Zhuo Li, Weiwei Chen, Yang Han, Ziyan Zhang, Yafen Yu, Qi Zhen, Liangdan Sun   +10 more
wiley   +1 more source

Mitochondrial Genome of the Indo-Pacific Mesophotic Coral <i>Leptoseris columna</i> (Scleractinia: Agariciidae) Assembled Using PacBio Long-Read Sequencing. [PDF]

Ecol Evol
Adhikary NR, Barshis DJ, Baeza JA.
europepmc   +1 more source

Discriminator‐Guided Inverse Folding for Multi‐Property Protein Design

Advanced Science, EarlyView.
Discriminator‐Guided Inverse Folding (DGIF) integrates multiple property predictors trained from single‐property datasets to guide protein sequence generation from a backbone structure. DGIF enables simultaneous improvement of thermostability and solubility without requiring multi‐property annotated datasets and generates designs that move toward the ...
Yuchuan Zheng, Chuyi Liu, Zhaoming Liu, Mao Su, Chenyu Tang, Xiang Zheng, Hao Zhang, Jingyuan Li   +7 more
wiley   +1 more source

Codon usage patterns and phylogenetic analysis of chloroplast genomes reveal evolutionary insights into Asphodelaceae species. [PDF]

Sci Rep
Zhang K, Li K, Feng J, Liu W, Feng J, Fan W, Shan X.   +6 more
europepmc   +1 more source

The DEAD-Box Protein Dhh1p Couples mRNA Decay and Translation by Monitoring Codon Optimality.

Cell, 2016
Aditya Radhakrishnan, Ying-Hsin Chen, Sophie Martin, Najwa Alhusaini, R. Green, J. Coller   +5 more
semanticscholar   +1 more source

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Enterohemorrhagic <i>Escherichia coli</i> O157:H7 responds to norepinephrine gradients by tRNA reprogramming and codon-biased translation of virulence genes. [PDF]

mSystems
McShane AE, Chan C-K, Chen R, DeMott MS, Begley TJ, Dedon PC.   +5 more
europepmc   +1 more source