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Estimate Codon Usage Bias Using Codon Usage Analyzer (CUA)
2017One amino acid is added to a growing peptide by a ribosome through reading triple nucleotides, i.e., a codon, each time. Twenty species of amino acids are often coded by 61 codons, so one amino acid can be coded by more than one codon and the codons coding the same amino acid are called synonymous. Intriguingly, synonymous codons' usage is often uneven:
Zhenguo, Zhang, Gaurav, Sablok
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The expanding world of tRNA modifications and their disease relevance
Nature Reviews Molecular Cell Biology, 2021Tsutomu Suzuki
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Sense codon reassignment enables viral resistance and encoded polymer synthesis
Science, 2021Wesley E Robertson +2 more
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The Ccr4-Not complex monitors the translating ribosome for codon optimality
Science, 2020Robert Buschauer +2 more
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The molecular basis of translation initiation and its regulation in eukaryotes
Nature Reviews Molecular Cell Biology, 2023Jailson Brito Querido +2 more
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Codon optimality, bias and usage in translation and mRNA decay
Nature Reviews Molecular Cell Biology, 2017Jeff Coller
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