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Estimate Codon Usage Bias Using Codon Usage Analyzer (CUA)
2017One amino acid is added to a growing peptide by a ribosome through reading triple nucleotides, i.e., a codon, each time. Twenty species of amino acids are often coded by 61 codons, so one amino acid can be coded by more than one codon and the codons coding the same amino acid are called synonymous. Intriguingly, synonymous codons' usage is often uneven:
Zhenguo, Zhang, Gaurav, Sablok
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Synonymous but Not Silent: The Codon Usage Code for Gene Expression and Protein Folding
Annual Review of Biochemistry, 2021Yi Liu, Qian Yang, Fangzhou Zhao
exaly
Sense codon reassignment enables viral resistance and encoded polymer synthesis
Science, 2021Wesley E Robertson +2 more
exaly
Codon optimality, bias and usage in translation and mRNA decay
Nature Reviews Molecular Cell Biology, 2017Jeff Coller
exaly
CODONS: A Microcomputer Program for Codon Usage Analysis
Journal of Heredity, 1992A T, Lloyd, P M, Sharp
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Synonymous but not the same: the causes and consequences of codon bias
Nature Reviews Genetics, 2010Grzegorz Kudła
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