Results 71 to 80 of about 1,545,063 (318)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Classes of analytic functions involving the q-Ruschweyh operator and q-Bernardi operator

AIMS Mathematics
In this paper, we introduced and studied two new classes of analytic functions using the concepts of subordination and q-calculus. We established inclusion relations for these q-classes and integral-preserving properties associated with the q-integral ...
Khadeejah Rasheed Alhindi, Khalid M. K. Alshammari, Huda Ali Aldweby   +2 more
doaj   +1 more source

Coefficient estimates for whole-plane SLE processes [PDF]

, 2011
Loewner introduced his famous differential equation in 1923 in order to solve Bieberbach conjecture for n=3. His method has been revived in 1999 by Ode Schramm who introduced Stochastic Loewner processes which happened to open many doors in statistical ...
Duplantier, Bertrand, Nguyen, Chi, Nguyen, Nga, Zinsmeister, Michel   +3 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Faber Polynomial Coefficient Estimates of m-Fold Symmetric Bi-Univalent Functions with Bounded Boundary Rotation

Mathematics
In the current article, we introduce several new subclasses of m-fold symmetric analytic and bi-univalent functions associated with bounded boundary and bounded radius rotation within the open unit disk D.
Anandan Murugan, Srikandan Sivasubramanian, Prathviraj Sharma, Gangadharan Murugusundaramoorthy   +3 more
doaj   +1 more source

On new subclass of meromorphically convex functions with positive coefficients [PDF]

Surveys in Mathematics and its Applications, 2019
In this paper we introduce and study a new subclass of meromorphically uniformly convex functions with positive coefficients defined by a differential operator and obtain coefficient estimates, growth and distortion theorem, radius of convexity, integral
B. Venkateswarlu , P. Thirupathi Reddy, N. Rani   +2 more
doaj  

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

The Variances of Regression Coefficient Estimates Using Aggregate Data [PDF]

This paper considers the effect of aggregation on the variance of parameter estimates for a linear regression model with random coefficients and an additive error term.
Edwin Kuh, Roy E. Welsch
core