Results 81 to 90 of about 2,637,288 (262)
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MathematicsThis paper establishes new results related to geometric function theory by presenting a new subclass of harmonic functions with complex values within the open unit disk, characterized by a second-order differential inequality.
Sibel Yalçın +2 more
doaj +1 more source
Subordination Implications and Coefficient Estimates for Subclasses of Starlike Functions
Mathematics, 2020 In the present paper, we consider various subclasses of star-like functions, which are defined by subordination and then we obtain several subordination implications related to these subclasses.
Nak Eun Cho +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Distributional Limits and GINI Coefficient. [PDF]
This paper examines the Gini (1912) coefficient of concentration using the framework set out by Dalton (1920) for evaluating a measure of inequality. Particular attention is paid to limited distributions and the associated concept of 'perfect inequality'.
Van de Ven, J.
core
Long run coefficient estimates of the nonlinear export model (F).
, 2023 Long run coefficient estimates of the nonlinear export model (F).
Ahmet Faruk Aysan (11902115) +4 more
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
The Variances of Regression Coefficient Estimates Using Aggregate Data [PDF]
This paper considers the effect of aggregation on the variance of parameter estimates for a linear regression model with random coefficients and an additive error term.
Roy E. Welsch, Edwin Kuh
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source