Results 111 to 120 of about 167,172,128 (305)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

"The Economic Consequences of Weintraub's Consumption Coefficient" [PDF]

In this paper we show that Weintraub:s consumption coefficient (the ratio of total consumption to wages) can elucidate trends in the sectoral and functional distributions of income We also show that, in a Kaleckian model, it simplifies and add precision ...
Anthony J. Laramie, Jan Toporowski, Douglas Mair   +2 more
core  

The Performance and Force Coefficients of Flapping Foil

, 2016
The added mass and damping coefficients of a flapping foil propulsor are investigated using an URANS method with the k-omega turbulence model for two Reynolds numbers. First, computed performance coefficients are compared with experimental results from the open literature.
Sánchez-Caja Antonio, Martio Jussi
openaire   +3 more sources

Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley   +1 more source

Asymptotically distribution free (adf) interval estimation of coefficient alpha [PDF]

Asymptotic distribution free (ADF) interval estimators for coefficient alpha were introduced in the context of an application by Yuan, Guarnaccia, and Hayslip (2003). Here, simulation studies were performed to investigate the behavior of ADF vs.
ALBERTO MAYDEU
core  

Random coefficient regressions: parametric goodness of fit tests [PDF]

, 1995
Random coefficient regression models have been applied in different fields during recent years and they are a unifying frame for many statistical models.
Delicado, Pedro, Romo, Juan
core   +1 more source

Special endurance coefficients enable the evaluation of running performance

Scientific Reports
Abstract Running performance from sprint to long distance is largely determined by the interplay between basic speed and endurance. Existing power-law, physiological, and theoretical models describe and explain the characteristic decline in pace with increasing distance.
Wolfgang Blödorn, Frank Döring
openaire   +3 more sources

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source