Results 51 to 60 of about 167,172,128 (305)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
, 2018 The study considered performance analysis and feedback from the perspective of the performance analyst through the investigation of the ‘what’, ‘how’ and ‘when’ of practice within a selection of Olympic sports.
Wells, Julia +3 more
core +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
, 2016 Promotional mailing (dated August 2016) for the University of Scranton Department of Performance Music, displaying concerts and events scheduled for the Fall 2016 semester.
University of Scranton. Department of Performance Music
core +1 more source
Effect of Refrigerant Charge on the Performance of Air-source Heat Pump Water Heater
Zhileng xuebao, 2018 In this paper, the effects of a refrigerant charge on the system performance of a heat pump water heater and the regulating characteristics of the electronic expansion valve were studied experimentally.
Yuan Zhaoyang +3 more
doaj
Performance Analysis of Coefficient of Performance (COP) in Refrigerants
This research paper presents a comprehensive review of the Coefficient of Performance (COP) in various refrigerants used in cooling systems. The study evaluates the thermodynamic properties, efficiency, and environmental impact of different refrigerants, focusing on both traditional and modern alternatives.
V. Jamadar, A. Awasare
openaire +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
SensorsIn this study, Klobuchar coefficients optimized for the Japanese region, referred to as the Klobuchar Regional (KR) model, were estimated using the International GNSS Service (IGS) Global Ionosphere Map (GIM) and evaluated against the Klobuchar GPS (KG) and Klobuchar QZSS (KQ) models.
Ei-Ju Sim, Kwan-Dong Park
openaire +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source