Results 51 to 60 of about 203,738,243 (304)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Goodness of fit tests in random coefficient regression models [PDF]

, 1994
Random coefficient regressions have been applied in a wide range of fields, from biology to economics, and constitute a common frame for several important statistical models.
Delicado, Pedro, Romo, Juan
core   +1 more source

Performance evaluation and sensitivity analysis of a low- capacity single-effect LiBr-H2O absorption cooling system using energy and exergy modeling

Journal of Applied Science and Engineering
In industrialized cooling systems, LiBr − H₂O is widely utilized as the predominant working fluid, particularly in absorption systems for maintaining the thermal comfort of building occupants.
Syed Maaz Hasan, Muhammad Saad Ul Haq, Abdul Waheed Badar, M Zahid Iqbal Qureshi, Majid Ali, M. Salman Siddiqi   +5 more
doaj   +1 more source

Performance Analysis of Coefficient of Performance (COP) in Refrigerants

This research paper presents a comprehensive review of the Coefficient of Performance (COP) in various refrigerants used in cooling systems. The study evaluates the thermodynamic properties, efficiency, and environmental impact of different refrigerants, focusing on both traditional and modern alternatives.
V. Jamadar, A. Awasare
openaire   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Studi Variasi Laju Pengeluaran Kalor Kondensor High Stage Sistem Refrigerasi Cascade Menggunakan Refrigeran MC22 dan R404A dengan Heat Exchanger Tipe Concentric Tube

Jurnal Teknik ITS, 2013
Masih adanya kekurangan pada alat penukar panas tipe compact yang digunakan pada sistem refrigerasi cascade sebelumnya, pada studi eksperimental ini dibuat kembali suatu sistem refrigerasi cascade dengan alat penukar panas tipe concentric.
Faberto Subrida, Ary Bachtiar Khrisna Putra   +1 more
doaj  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Computational Study of the Electronic Performance of Cross-Plane Superlattice Peltier Devices [PDF]

, 2011
We use a state-of-the-art non-equilibrium quantum transport simulation code, NEMO- 1D, to address the device physics and performance benchmarking of cross-plane superlattice Peltier coolers.
Gerhard Klimeck, Lundstrom, M., Jeong, Changwook, Klimeck, Gerhard, Klimeck, G., Changwook Jeong, Mark Lundstrom, Lundstrom, Mark S.   +7 more
core   +1 more source