Results 71 to 80 of about 167,172,128 (305)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Empirical Evaluation of the Relative Forecasting Performances of Fixed and Varying Coefficient Demand Models [PDF]

open access: yes
The forecast performances of the fixed coefficient demand model are compared with those of spline function and the Cooley-Prescott varying parameter demand models using consumption and price data for beef, pork, chicken and turkey.
Hammig, Michael D.   +1 more
core  

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Establishing the golden range of Seebeck coefficient for maximizing thermoelectric performance

open access: yes, 2020
The coupling nature of thermoelectric properties determines that optimizing the Fermi level is the priority to achieve a net increase in thermoelectric performance. Conventionally, the carrier concentration is used as the reflection of the Fermi level in
Hong, Min   +10 more
core   +1 more source

Understanding Anti-performance: The performative division of experience and the standpoint of the non-performer [PDF]

open access: yes, 2020
Performance theorists have long been drawn to the potential of performance to subvert established institutions. The results of performance are never fully determined in advance; performances subject established images to reinterpretation; they take place
Joseph Grim Feinberg   +1 more
core   +1 more source

Performance Music: Virtual Choir of SATB Arrangement

open access: yes, 2020
University of Scranton Performance Music Instagram post regarding a virtual choir with an SATB ...
University of Scranton. Department of Performance Music
core   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Performance audits

open access: yes, 2007
Title from PDF cover (viewed on Feb. 25, 2008).; "Mary Taylor, CPA, Auditor of State."; "Partnering with Ohio to promote efficient service and accountability."; "Created: 7/13/2007 ..."--Document properties screen.; Harvested from the web on 2/25 ...
Ohio. Auditor of State.
core  

Optimal calibration in immunoassay and inference on the coefficient of variation [PDF]

open access: yes, 2008
This thesis examines and develops statistical methods for design and analysis with applications in immunoassay and other analytical techniques. In immunoassay, concentrations of components in clinical samples are measured using antibodies.
Forkman, Johannes
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

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