Results 51 to 60 of about 2,378,304 (340)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Effects of Varying the Three-Body Molecular Hydrogen Formation Rate in Primordial Star Formation [PDF]

open access: yes, 2010
The transformation of atomic hydrogen to molecular hydrogen through three-body reactions is a crucial stage in the collapse of primordial, metal-free halos, where the first generation of stars (Population III stars) in the Universe are formed.
/Garching, Max Planck Inst. Plasmaphys.   +11 more
core   +3 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A differential cluster variation method for analysis of spiniodal decomposition in alloys

open access: yes, 2002
A differential cluster variation method (DCVM) is proposed for analysis of spinoidal decomposition in alloys. In this method, lattice symmetry operations in the presence of an infinitesimal composition gradient are utilized to deduce the connection ...
Gao, Huajian, Liu, Zhi-Rong
core   +1 more source

Fluctuations of the Shannon capacity in a Raleigh model of wireless communication [PDF]

open access: yes, 2004
Using the fact that the Shannon capacity C of a Raleigh model of wireless channels is a linear statistic of the channel matrix, we calculate its variance var[C]. We find that the expected value of the Shannon capacity is typical in the model considered,
Beenakker   +14 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Variation of the Fine-Structure Constant and Laser Cooling of Atomic Dysprosium

open access: yes, 2008
Radio-frequency electric-dipole transitions between nearly degenerate, opposite parity levels of atomic dysprosium (Dy) were monitored over an eight-month period to search for a variation in the fine-structure constant, $\alpha$.
Budker, D.   +8 more
core   +3 more sources

Variability in heart rate recovery measurements over 1 year in healthy, middle-aged adults. [PDF]

open access: yes, 2014
This study assessed the longer-term (12-month) variability in post-exercise heart rate recovery following a submaximal exercise test. Longitudinal data was analysed for 97 healthy middle-aged adults (74 male, 23 female) from 2 occasions, 12 months apart.
Carroll, S, Ingle, L, Mellis, MG
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Research on 2×2 MIMO Channel with Truncated Laplacian Azimuth Power Spectrum [PDF]

open access: yes, 2013
Multiple-input multiple-output (MIMO) Rayleigh fading channel with truncated Laplacian azimuth power spectrum (APS) is studied. By using the power correlation matrix of MIMO channel model and the modified Jakes simulator, into which with random phases ...
Wu, Q., Yang, X.-S., Zhang, Y.-T.
core   +1 more source

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