Results 71 to 80 of about 174,135,443 (297)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Estimation of genetic variability, heritability and genetic advance as percent mean in black turmeric (Curcuma caesia Roxb.) genotypes

Electronic Journal of Plant Breeding
Genetic variability, heritability, and genetic advance were evaluated in 33 genotypes of black turmeric (Curcuma caesia Roxb.) to identify traits suitable for effective selection.
A.B. Mohan Kumar, M. Vasundhara, H.P. Rajath, G.S. Yogesh   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Analysis of Vertical Heterogeneity Measures Based on Routine Core Data of Sandstone Reservoirs

Geosciences
Heterogeneous reservoirs are prevalent; otherwise, they are rare. The problem is detecting the degree of such heterogeneity, which has a significant impact on hydrocarbon production in oilfields. Several vertical heterogeneity measures were introduced to
Mohamed S. El Sharawy
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Distribution and variation of the convective heat transfer coefficient.

, 2022
Distribution and variation of the convective heat transfer coefficient.
Yue Zhang (30585), Hua Song (113155), Jian Yang (12136), Ming-Xin Gao (10987307)   +3 more
core   +1 more source

Variability Studies in F3 population of Three Crosses in Groundnut (Arachis hypogaea L.)

Madras Agricultural Journal, 2012
Groundnut is an important legume crop and is used as a food, oil and cash source. Mean and variability are the important factors for selection and they overcome the problems of handling larger segregating populations.
D. Shoba, N. Manivannan and P. Vindhiyavarman   +1 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Evaluation of hydraulic characteristics of several types of drip irrigation tapes

علوم آب و خاک, 2017
The main purpose of this study is investigation of hydraulic properties in drip irrigation tape. In this study, 10 types of drip irrigation tape were tested, and the effect of 4 temperatures of water, 13, 23, 33 and 43 °C, was investigated according to ...
F. Gavazi, E. Maroufpoor
doaj  

Assessment of Agro-Morphologic Performance, Genetic Parameters and Clustering Pattern of Newly Developed Blast Resistant Rice Lines Tested in Four Environments

Agronomy, 2020
Multi-environmental yield trial is very vital in assessing newly developed rice lines for its adaptability and stability across environments especially prior to release of the newly developed variety for commercial cultivation. The growth performance and
Raieah Saiyedah Sabri, Mohd Y. Rafii, Mohd Razi Ismail, Oladosu Yusuff, Samuel C. Chukwu, Nor’Aishah Hasan   +5 more
doaj   +1 more source