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Glowing jellyfish, luminescence and a molecule called coelenterazine
Trends in Biotechnology, 1999Luminescence has assumed an important role in analytical biochemistry and molecular biology as an extremely sensitive method for determining the concentration of specific ions and molecules. The luminescent system of the jellyfish Aequorea victoria consists of the photoprotein aequorin, which contains the molecule coelenterazine as a prosthetic group ...
K, Jones, F, Hibbert, M, Keenan
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Regiospecific Coelenterazine Analogs for Bioassays and Molecular Imaging
Bioconjugate ChemistryBioluminescence (BL) generated by luciferase-coelenterazine (CTZ) reactions is broadly employed as an optical readout in bioassays and in vivo molecular imaging. In this study, we demonstrate a systematic approach to elucidate the luciferase-CTZ binding chemistry with a full set of regioisomeric CTZ analogs, where all the functional groups were ...
Genta Kamiya +7 more
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Biochemical and Biophysical Research Communications
Dehydrocoelenterazine (dCTZ) is a dehydrogenated form of coelenterazine (CTZ), which is well-known as the luciferin responsible for the bioluminescence reaction in marine organisms. In this report, we demonstrate for the first time that dCTZ is readily reduced to CTZ in mammalian cells.
Satoshi Inouye +4 more
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Dehydrocoelenterazine (dCTZ) is a dehydrogenated form of coelenterazine (CTZ), which is well-known as the luciferin responsible for the bioluminescence reaction in marine organisms. In this report, we demonstrate for the first time that dCTZ is readily reduced to CTZ in mammalian cells.
Satoshi Inouye +4 more
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COELENTERAZINE-DEPENDENT LUCIFERASES: PROPERTIES AND APPLICATION
Lomonosov chemistry journalThe review presents data on the structure of bioluminescent systems of marine animals that use coelenterazine-dependent luciferases as light-emitting proteins. It has been shown that due to the availability, stability and high quantum yield of reactions, these luciferases, as well as their genetic variants with new useful properties, are successfully ...
L.A. FRANK, V.V. KRASITSKAYA
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Comparative Investigation of the Chemiluminescent Properties of a Dibrominated Coelenterazine Analog
International Journal of Molecular Sciences, 2022Patricia González-Berdullas +1 more
exaly
Biochemical and Biophysical Research Communications, 2021
Hiromitsu Endo, José Paitio, Yuichi Oba
exaly
Hiromitsu Endo, José Paitio, Yuichi Oba
exaly