Results 131 to 140 of about 419,459 (324)

Engineering a nicotinamide mononucleotide redox cofactor system for biocatalysis

Nature Chemical Biology, 2019
William B. Black, Linyue Zhang, W. S. Mak, Sarah Maxel, Youtian Cui, Edward King, B. Fong, Alicia Sanchez Martinez, J. Siegel, Han Li   +9 more
semanticscholar   +1 more source

Clinofibrate Disrupts the SNORA80B/YTHDC1‐Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC

Advanced Science, EarlyView.
This study uncovers a non‐canonical role of SNORA80B in ESCC, showing it mediates AR‐driven metabolic reprogramming via N⁶‐methyladenosine (m6A) methylation. By binding YTHDC1, SNORA80B stabilizes cholesterol‐metabolic enzyme mRNAs and promotes tumor progression. The FDA‐approved drug clinofibrate inhibits SNORA80B by disrupting cholesterol homeostasis,
Hongyu Yuan, Ge Ge, LiQiu Liu, Sijun Hu, Miaomiao Tian, Yongzhan Nie, Zitong Zhao, Yongmei Song   +7 more
wiley   +1 more source

A conserved aspartate residue in [4Fe-4S]-containing HypD is required for [NiFe]-cofactor biosynthesis and for efficient interaction of the HypCD scaffold complex with HypE [PDF]

Alexander Haase, Christian Arlt, Maximilian Hardelt, Andrea Sinz, R. Gary Sawers   +4 more
openalex   +1 more source

Co-ordinate variations in methylmalonyl-CoA mutase and methionine synthase, and the cobalamin cofactors in human glioma cells during nitrous oxide exposure and the subsequent recovery phase [PDF]

, 1999
Bettina RIEDEL, Torunn FISKERSTRAND, Helga REFSUM, Per Magne Ueland   +3 more
openalex   +1 more source

NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1

Advanced Science, EarlyView.
NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou, Sen Yang, Andrea Enriquez, Nino A. Espinas, Anoosha Sri, Caliel D. Hines, Jason M. Tennessen, Chia‐Shan Wu, Jui‐Yen Huang, Hui‐Chen Lu   +9 more
wiley   +1 more source

Raw diffraction images of nitrobindin mutant NB4H from Arabidopsis thaliana bound to artificial cofactor MnPPIX (PDB 7BBM)

, 2020
Alexander Minges, Daniel F. Sauer, Malte Wittwer, Ulrich Markel, Markus Spiertz, Johannes Schiffels, Mehdi D. Davari, Jun Okuda, Ulrich Schwaneberg, Georg Groth   +9 more
openalex   +1 more source

Engineering cofactor metabolism for improved protein and glucoamylase production in Aspergillus niger [PDF]

, 2020
Yufei Sui, Tabea Schütze, Liming Ouyang, Hongzhong Lu, Peng Liu, Xianzun Xiao, Jie Qi, Yingping Zhuang, Vera Meyer   +8 more
openalex   +1 more source

Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription

Cell, 2000
Yongfeng Shang, Xiao Hu, J. Direnzo, M. Lazar, Myles A. Brown   +4 more
semanticscholar   +1 more source

Ubc9‐Mediated SUMOylation of RPL3, an Unappreciated Mechanism against Hepatocyte Senescence by Repressing the DHX9‐p16 Axis

Advanced Science, EarlyView.
Liver aging is characterized by a decline in the expression of the SUMO‐conjugating enzyme Ubc9, resulting in reduced SUMOylation levels in hepatocytes, particularly in the case of ribosomal protein RPL3. Disruption of RPL3 SUMOylation increases its nuclear translocation. Interestingly, ribosome‐free RPL3 facilitates the recruitment of helicase DHX9 to
Hao Xie, Zhichao Gao, Xin Liu, Shiyi Zhang, Yuhan Wang, Jia Gao, Ping Qi, Lu Zhang, Jiawei Zhao, Tian Xiong, Teng Huang, Jia Song, Qilin Yu, Shu Zhang, Yanjun Liu, Ping Yang, Maryam S. Al‐Motawa, Quan Gong, Junfeng Dong, Hao Yin, Fei Sun, Shiwei Liu, Cong‐Yi Wang   +22 more
wiley   +1 more source

Structural basis for HIV‐1 DNA integration in the human genome, role of the LEDGF/P75 cofactor

, 2009
Fabrice Michel, Corinne Crucifix, Florence Granger, Sylvia Eiler, Jean‐François Mouscadet, S.V. Korolev, Julia Agapkina, Rustam Ziganshin, Marina Gottikh, Alexis Nazabal, Stéphane Emiliani, Richard Benarous, Dino Moras, Patrick Schultz, Marc Ruff   +14 more
openalex   +1 more source