Results 151 to 160 of about 245,562 (365)

Engineering the Immune Response to Biomaterials

open access: yesAdvanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam   +12 more
wiley   +1 more source

Global $W^{2,p}$ regularity on the linearized Monge-Amp$\grave{e}$re equation with $\mathrm{VMO}$ type coefficients [PDF]

open access: yesarXiv, 2018
In this paper, we establish global $W^{2,p}$ estimates for solutions of the linearized Monge-Amp$\grave{e}$re equation $$\mathcal{L}_{\phi}u:=\mathrm{tr}[\Phi D^2 u]=f,$$ where the density of the Monge-Amp$\grave{e}$re measure $g:=\mathrm{det}D^2\phi$ satisfies a $\mathrm{VMO}$-type condition, and $\Phi:=(\mathrm{det}D^2\phi)(D^2\phi)^{-1}$ is the ...
arxiv  

Novel target and cofactor repertoire for the transcriptional regulator JTY_0672 from Mycobacterium bovis BCG

open access: yesFrontiers in Microbiology
Mycobacterium tuberculosis (Mtb) is the pathogenic agent of tuberculosis (TB). Intracellular survival plays a central role in the pathogenesis of Mtb in a manner that is dependent on an array of transcriptional regulators for Mtb.
Hui Wang   +8 more
doaj   +1 more source

Antagonist Targeting the Species‐Specific Fatty Acid Dehydrogenase/Isomerase FabX for Anti‐H. pylori Infection

open access: yesAdvanced Science, EarlyView.
This study demonstrates that the atypical dehydrogenase/isomerase FabX in Type‐II fatty acid biosynthesis pathway is essential for H. pylori infection by retaining unsaturated fatty acid synthesis and producing superoxide (ROS). A small molecule FBX‐1991 that specifically targets FabX to inhibit H.
Lin Zhang   +9 more
wiley   +1 more source

Interior $C^{1,α}$ regularity on the linearized Monge-Amp$\grave{e}$re equation with $\mathrm{VMO}$ type coefficients [PDF]

open access: yesarXiv, 2018
In this paper, we establish interior $C^{1,\alpha}$ estimates for solutions of the linearized Monge-Amp$\grave{e}$re equation $$\mathcal{L}_{\phi}u:=\mathrm{tr}[\Phi D^2 u]=f,$$ where the density of the Monge-Amp$\grave{e}$re measure $g:=\mathrm{det}D^2\phi$ satisfies a $\mathrm{VMO}$-type condition and $\Phi:=(\mathrm{det}D^2\phi)(D^2\phi)^{-1}$ is ...
arxiv  

Mitofusin 1 Drives Preimplantation Development by Enhancing Chromatin Incorporation of Histone H3.3

open access: yesAdvanced Science, EarlyView.
MFN1 exerts its function partially through histone H3.3 in early embryos. MFN1 colocalizes with PADI6, and its deficiency results in compromised cytoplasmic lattices and ribosomal subunits, leading to declined H3.3 protein level. This, in turn, hinders the incorporation of H3.3 into the embryonic genome, thereby causing failure of male pronucleus ...
Xiao‐yan Shi   +9 more
wiley   +1 more source

Reversible High‐Affinity Binding of Coagulation Factor Xa to Zeolites Induces Accelerated Blood Coagulation

open access: yesAdvanced Science, EarlyView.
A calcium‐dependent, specific biorecognition between coagulation factor Xa (FXa) and zeolite is discovered. It alters the prothrombin activation pathway to a more efficient mechanism by mimicking the FXa/factor Va (FXa/FVa) interaction formed during the natural coagulation cascade.
Chaojie Shi   +9 more
wiley   +1 more source

Hydrogen Drives Part of the Reverse Krebs Cycle under Metal or Meteorite Catalysis

open access: yesAngewandte Chemie International Edition, Volume 61, Issue 51, December 19, 2022., 2022
Hydrogen is a geological reducing agent that powers the metabolisms of modern organisms and potentially also powered the metabolism of the last universal common ancestor to all extant life. It is shown that catalytic amounts of transition metals or small amounts of powdered meteorites allow hydrogen to drive a key sequence of the reverse Krebs cycle ...
Sophia A. Rauscher, Joseph Moran
wiley   +1 more source

Boosting lignan-precursor synthesis in yeast cell factories through co-factor supply optimization

open access: yesFrontiers in Bioengineering and Biotechnology, 2022
Jennifer Perrin   +3 more
doaj   +1 more source

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