Results 281 to 290 of about 419,459 (324)
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Novel cofactor derivatives and cofactor-based models
Current Opinion in Chemical Biology, 1998In 1997 and the first half of 1998, numerous publications appeared reporting studies of cofactors and their analogues in classical model systems and in enzyme-catalyzed reactions directed at understanding the enzymatic reactions of their natural cofactors. Model systems based on flavins have provided new insights into enzymatic modulation of the flavin
P K, Mishra, D G, Drueckhammer
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2009
Cofactors are organic molecules, most of them originating from vitamins, that bind to enzymes making them able to catalyze defined reactions. A cofactor-based chemogenomics approach exploits the presence of a cofactor-binding domain to develop compound scaffolds tailored to mimic the cofactor and to replace it within target enzyme classes. As a result,
SINGH R, MOZZARELLI, Andrea
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Cofactors are organic molecules, most of them originating from vitamins, that bind to enzymes making them able to catalyze defined reactions. A cofactor-based chemogenomics approach exploits the presence of a cofactor-binding domain to develop compound scaffolds tailored to mimic the cofactor and to replace it within target enzyme classes. As a result,
SINGH R, MOZZARELLI, Andrea
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Science, 2019
A mystery of bacterial chromosome segregation is explained by a nucleotide ...
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A mystery of bacterial chromosome segregation is explained by a nucleotide ...
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Evaluation of cofactor responsiveness
Journal of Inherited Metabolic Disease, 1985AbstractThe response to cofactor therapy in inborn errors of metabolism may be dramatic with complete resolution of the clinical illness but more commonly the response is absent or partial. When assessing cofactor responsiveness clinical and biochemical findings as well as the natural history of the disorder must be taken into account.
J V, Leonard, P, Daish
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Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast
Nature Chemical Biology, 2022Ruibing Chen +7 more
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The Cofactor Pyrroloquinoline Quinone
Annual Review of Nutrition, 1990Article de synthese sur un cofacteur: la pyrroloquinoleine quinone. Etude de ses proprietes; caracteristiques, formes moleculaires, stabilite. Identification et analyse quantitative des formes libres, derivees et liees par liaison covalente. Distribution chez les procaryotes, les eucaryotes, les aliments et les boissons.
J A, Duine +2 more
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Natural Product Reports, 2007
Cells require metal ions as cofactors for the assembly of metalloproteins. Principally one has to distinguish between metal ions that are directly incorporated into their cognate sites on proteins and those metal ions that have to become part of prosthetic groups, cofactors or complexes prior to insertion of theses moieties into target proteins ...
Ralf R, Mendel +3 more
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Cells require metal ions as cofactors for the assembly of metalloproteins. Principally one has to distinguish between metal ions that are directly incorporated into their cognate sites on proteins and those metal ions that have to become part of prosthetic groups, cofactors or complexes prior to insertion of theses moieties into target proteins ...
Ralf R, Mendel +3 more
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1992
MCP serves to down-regulate the activation of complement on host tissue. It performs this function by serving as a cofactor for the factor I-mediated cleavage of C3b and C4b. MCP is most likely an intrinsic regulator, i.e., it primarily protects its home cell.
M K, Liszewski, J P, Atkinson
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MCP serves to down-regulate the activation of complement on host tissue. It performs this function by serving as a cofactor for the factor I-mediated cleavage of C3b and C4b. MCP is most likely an intrinsic regulator, i.e., it primarily protects its home cell.
M K, Liszewski, J P, Atkinson
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Prothrombin as cofactor for antiphospholipids
Lupus, 1998Prothrombin is a common antigenic target of antiphospholipid antibodies, since anti-prothrombin antibodies are detected in about 50-90% of the patients. To allow proper immune recognition, prothrombin must be adsorbed on suitable anionic surfaces. The epitope(s) have not yet been identified: the majority of anti-prothrombin antibodies appear to be of ...
M, Galli, T, Barbui
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1978
It is known that many enzymes function only in conjunction with a coenzyme (cofactor) which is generally a compound of low molecular weight. Immobilization of these compounds has been the focus of much effort because of their potential as bioaffinity ligands and in the search for immobilized coenzymes retaining “biological activity”, which are readily ...
K. Mosbach, P.-O. Larsson
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It is known that many enzymes function only in conjunction with a coenzyme (cofactor) which is generally a compound of low molecular weight. Immobilization of these compounds has been the focus of much effort because of their potential as bioaffinity ligands and in the search for immobilized coenzymes retaining “biological activity”, which are readily ...
K. Mosbach, P.-O. Larsson
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