Results 281 to 290 of about 418,378 (371)

Blood α‐Synuclein Separates Parkinson's Disease from Dementia with Lewy Bodies

Annals of Neurology, EarlyView.
Objective Aggregation of misfolded α‐synuclein (aSyn) within the brain is the pathologic hallmark of Lewy body diseases (LBDs), including Parkinson's disease (PD), and dementia with Lewy bodies (DLB) disease. Although evidence exists for aSyn “strains,” conformations with distinct biological properties, biomarkers for PD versus DLB are lacking.
George T. Kannarkat, Rebecca Zack, R. Tyler Skrinak, James F. Morley, Roseanne Davila‐Rivera, Sanaz Arezoumandan, Katherine Dorfman, Kelvin Luk, David A. Wolk, Daniel Weintraub, Thomas F. Tropea, Edward B. Lee, Sharon X. Xie, Ganesh Chandrasekaran, Virginia M.‐Y. Lee, David Irwin, Rizwan S. Akhtar, Alice S. Chen‐Plotkin   +17 more
wiley   +1 more source

Conformation-gated binding underlies kinetic asymmetry and negative cooperativity in ATP:cob(I)alamin adenosyltransferase. [PDF]

Cell Rep Phys Sci
Yan G, Pan M, Keller AM, Santiago AG, Lofgren M, Banerjee R, Chen P, Chen TY.   +7 more
europepmc   +1 more source

nifV-dependent, low-molecular-weight factor required for in vitro synthesis of iron-molybdenum cofactor of nitrogenase

, 1986
Timothy R. Hoover, Vinod K. Shah, G P Roberts, Paul W. Ludden   +3 more
openalex   +1 more source

Targeted Proteomics upon Treatment with Tofersen Identifies Novel Response Markers for Superoxide Dismutase 1‐Linked Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Tofersen is the first effective and approved therapy for superoxide dismutase 1 (SOD1)‐associated amyotrophic lateral sclerosis (ALS [SOD1‐ALS]). Following treatment with tofersen, neurofilament levels in patients' cerebrospinal fluid (CSF) and serum seem to respond earlier than clinical parameters.
Christina Steffke, Karthik Baskar, Franziska Bachhuber, Maximilian Wiesenfarth, Johannes Dorst, Joachim Schuster, Florian Schöberl, Peter Reilich, Martin Regensburger, Alexander German, René Günther, Maximilian Vidovic, Susanne Petri, Thomas Meyer, Tim Hagenacker, Julian Grosskreutz, Ute Weyen, Patrick Weydt, Thomas Haarmeier, Paul Lingor, Joachim Wolf, Andreas Hermann, Johannes Prudlo, Kornelia Günther, Antje Knehr, Zeynep Elmas, Zeljko Uzelac, Simon Witzel, Wolfgang Philipp Ruf, Axel Freischmidt, Ritchie Ho, Albert C. Ludolph, Jochen H. Weishaupt, Hayrettin Tumani, Patrick Oeckl, David Brenner, Alberto Catanese   +36 more
wiley   +1 more source

Cupin‐Type Dimethylsulfoniopropionate Lyase from Pelagibacter ubique (DddKPu) Catalyzes Aza‐Michael Addition of Primary and Secondary Amines to Acrylic Acid

Angewandte Chemie, EarlyView.
A dimethylsulfoniopropionate lyase (DddK) was identified as an efficient aza‐Michaelase for the addition of amines to acrylate. Screening 74 amines with wild‐type DddK and its W26G variant yielded N‐substituted and N,N‐disubstituted β‐amino acids in 30%–93% isolated yield.
Diletta Arceri, Angela Mourelle, Teodor Parella, Jordi Bujons, Carlos J. Moreno, Pere Clapés   +5 more
wiley   +2 more sources

Biosynthesis and assembly of hydrogenase [NiFe]-cofactor: recent advances and perspectives. [PDF]

Metallomics
Sawers RG, Hardelt M, Haase A, Lubek D.
europepmc   +1 more source

Nucleic Acid‐Based Molecular Machines for Biological Applications

Advanced NanoBiomed Research, EarlyView.
Molecular machines are devices assembled from molecules with specific functions. In this review, the development of DNA nanostructures, which are then assembled into molecular machines, is summarized. Their classification and biological applications, such as biosensing, targeted therapy, and molecular circuits are introduced.
Yirong Guo, Xiaolei Zuo, Fangfei Yin
wiley   +1 more source

Reduced Pressure Ionization Enhances Native Mass Spectrometry of Proteins and Protein Complexes

Angewandte Chemie, EarlyView.
Reduced pressure for electrospray ionization of native proteins narrows peak widths and increases signal. This straightforward add‐on to existing native MS platforms improves performance in challenging buffers and enables detection of protein interactions at concentrations as low as 50 nM, without significantly disrupting structure as confirmed by ...
Jake P. Violi, Chong Zhang, William A. Donald   +2 more
wiley   +2 more sources

Covalent Irreversible Inhibitors of Tetracycline Destructases. [PDF]

ACS Infect Dis
Li R, Xue YP, Le ST, Tang WK, Tolia NH, Dantas G, Wencewicz TA.   +6 more
europepmc   +1 more source

Endogenously Triggered DNAzyme‐Based Nanostructures for Gene‐Combined Therapy

Advanced NanoBiomed Research, EarlyView.
DNAzymes show great promise for gene regulation and therapeutic use via controlled release triggered by endogenous factors. This review summarizes recent advances in designing and constructing nanoscale platforms enabling endogenously triggered release of DNAzyme.
Theoneste Muyizere, Julien Milon Essola, Eric Nyirimigabo, Janvier Mukiza, Jean Felix Mukerabigwi   +4 more
wiley   +1 more source