Results 291 to 300 of about 418,378 (371)

Amyloid Peptide Nanofibrils Promote Efficient Neurotransmitter Oxidation and Serve as Scaffolds for Melanin Production

Angewandte Chemie, EarlyView.
Short amyloid peptides can act as efficient catalysts of neurotransmitter degradation, and libraries of short peptides can be used to identify core fragments present in larger proteins that might be linked to neurodegenerative diseases. Abstract We have shown that de novo designed peptides self‐assemble in the presence of copper to create ...
Inhye Kim, Liam R. Marshall, Shams Aaghaz, Yang Li, Ho Yee Joyce Fung, Ivan V. Korendovych   +5 more
wiley   +2 more sources

A Systems Hypothesis of Lipopolysaccharide-Induced Vitamin Transport Suppression and Metabolic Reprogramming in Autism Spectrum Disorders: An Open Call for Validation and Therapeutic Translation. [PDF]

Metabolites
Dervishi A.
europepmc   +1 more source

Cyanide and Methylisocyanide Binding to the Isolated Iron-Molybdenum Cofactor of Nitrogenase

, 1989
Steven D. Conradson, Barbara K. Burgess, Stephen A. Vaughn, A. Lawrence Roe, Britt Hedman, Keith O. Hodgson, R. H. Holm   +6 more
openalex   +1 more source

Switching Enantioselectivity in Phenylalanine Ammonia Lyase for the Synthesis of Electron‐Deficient Aromatic d‐Amino Acids

Angewandte Chemie, EarlyView.
Phenylalanine ammonia lyases (PALs) were engineered to switch enantioselectivity, enabling hydroamination for the direct synthesis of electron‐deficient aromatic d‐amino acids (d‐AA). Structure‐guided engineering provided PAL variants with broad substrate scope, high activity, and excellent d‐selectivity, broadening the utility of PALs in asymmetric ...
Ivan Buslov, Sarah Desmons, Weijin Wang, Laura Elena Massaad, Xile Hu   +4 more
wiley   +2 more sources

A path to perpetual chemical synthesis <i>via</i> photocatalytic cofactor regeneration. [PDF]

Chem Sci
Jain V, Pillai PP.
europepmc   +1 more source

Studies of α′,β′‐Epoxyketone Synthesis by Small‐Molecule Flavins and Flavoenzymes

Angewandte Chemie, EarlyView.
A combined synthetic and biochemical approach links the flavoenzyme EpxF to three key steps in epoxomicin biosynthesis. Crystallography, mutagenesis, and 13C‐labeling complete the mechanistic picture of α′,β′‐epoxyketone formation and illustrate the potential of flavin‐mediated transformations.
Alexandra Walter, Wolfgang Kuttenlochner, Wolfgang Eisenreich, Chengyang Yao, Michael Groll, Golo Storch   +5 more
wiley   +2 more sources

Using BONCAT to dissect the proteome of <i>S. aureus</i> persisters. [PDF]

mSphere
George Matlalcuatzi EDC, Bakkum T, Thomas PS, Hacker S, Florea BI, Vriesendorp B, Rozen DE, van Kasteren SI.   +7 more
europepmc   +1 more source

Metabolic Engineering of the 5-Aminolevulinate Biosynthetic Pathway in E. coli Improves Efficiency of Hemoprotein-Based Biocatalysis. [PDF]

Angew Chem Int Ed Engl
Kato S, Abe M, Okahashi N, Ariyasu S, Matsuda F, Shoji O, Hayashi T.   +6 more
europepmc   +1 more source

Modification of lysine residues in proteins: a novel posttranslational effect of vitamin C. [PDF]

Signal Transduct Target Ther
Kabelitz D.
europepmc   +1 more source

Single‐Molecule DNA Tweezers Enable Programmable Control of Enzyme Activity via Arbitrary Molecular Cues

Angewandte Chemie, EarlyView.
Controlling enzyme activity with molecular precision remains a fundamental challenge. Here, we present a DNA‐based strategy for the dynamic and programmable regulation of enzyme function in response to arbitrary, user‐defined chemical cues. We report the development of single‐molecule DNA tweezers (SMDTs)—structures that can be programmed to bind and ...
Shivudu Godhulayyagari, Sara R. Nixon, Devleena Samanta   +2 more
wiley   +1 more source