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Round, round we go - strategies for enzymatic cofactor regeneration.
Natural product reports (Print), 2020Covering: up to the beginning of 2020Enzymes depending on cofactors are essential in many biosynthetic pathways of natural products. They are often involved in key steps: catalytic conversions that are difficult to achieve purely with synthetic organic ...
Silja Mordhorst, J. Andexer
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Science, 2019 A mystery of bacterial chromosome segregation is explained by a nucleotide ...
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Advanced Functional Materials, 2019
Over the past decade, the catalytic activity of nanozymes has been greatly enhanced, but their selectivity is still low and considered a critical issue to overcome. Herein, Fe–N4 single site embedded graphene (Fe–N‐rGO), which resembles the heme cofactor
M. Kim +9 more
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Over the past decade, the catalytic activity of nanozymes has been greatly enhanced, but their selectivity is still low and considered a critical issue to overcome. Herein, Fe–N4 single site embedded graphene (Fe–N‐rGO), which resembles the heme cofactor
M. Kim +9 more
semanticscholar +1 more source
8. The Cofactors of Nitrogenases
2020In biological nitrogen fixation, the enzyme nitrogenase mediates the reductive cleavage of the stable triple bond of gaseous N2at ambient conditions, driven by the hydrolysis of ATP, to yield bioavailable ammonium (NH4+). At the core of nitrogenase is a complex, ironsulfur based cofactor that in most variants of the enzyme contains an additional ...
Djurdjevic, Ivana +7 more
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Cofactor dependent and cofactor independent anticardiolipin antibodies
Thrombosis Research, 1991Two distinct types of anticardiolipin antibodies are described, one of which requires the presence of a serum factor (cofactor) to bind cardiolipin in ELISA and liposome affinity systems. The second type does not require this cofactor. The requirement of a cofactor for the binding of some but not all anticardiolipin antibodies provides an explanation ...
N. S. Pattison +2 more
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Novel cofactor derivatives and cofactor-based models
Current Opinion in Chemical Biology, 1998In 1997 and the first half of 1998, numerous publications appeared reporting studies of cofactors and their analogues in classical model systems and in enzyme-catalyzed reactions directed at understanding the enzymatic reactions of their natural cofactors. Model systems based on flavins have provided new insights into enzymatic modulation of the flavin
Dale G. Drueckhammer, Pranab Mishra
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Evaluation of cofactor responsiveness
Journal of Inherited Metabolic Disease, 1985AbstractThe response to cofactor therapy in inborn errors of metabolism may be dramatic with complete resolution of the clinical illness but more commonly the response is absent or partial. When assessing cofactor responsiveness clinical and biochemical findings as well as the natural history of the disorder must be taken into account.
P. Daish, J. V. Leonard
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2009
Cofactors are organic molecules, most of them originating from vitamins, that bind to enzymes making them able to catalyze defined reactions. A cofactor-based chemogenomics approach exploits the presence of a cofactor-binding domain to develop compound scaffolds tailored to mimic the cofactor and to replace it within target enzyme classes. As a result,
SINGH R, MOZZARELLI, Andrea
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Cofactors are organic molecules, most of them originating from vitamins, that bind to enzymes making them able to catalyze defined reactions. A cofactor-based chemogenomics approach exploits the presence of a cofactor-binding domain to develop compound scaffolds tailored to mimic the cofactor and to replace it within target enzyme classes. As a result,
SINGH R, MOZZARELLI, Andrea
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Hierarchies of cofactor systems
Journal of Physics A: Mathematical and General, 2002Summary: We assign to any cofactor system a whole hierarchy of such systems. A sufficient condition for their complete integrability is given. The hierarchies admit construction of nontrivial integrable systems from trivial ones.
Peter Topalov, Peter Topalov
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The Cofactor Pyrroloquinoline Quinone
Annual Review of Nutrition, 1990Article de synthese sur un cofacteur: la pyrroloquinoleine quinone. Etude de ses proprietes; caracteristiques, formes moleculaires, stabilite. Identification et analyse quantitative des formes libres, derivees et liees par liaison covalente. Distribution chez les procaryotes, les eucaryotes, les aliments et les boissons.
R. A. van der Meer +2 more
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