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8. The Cofactors of Nitrogenases
2020In biological nitrogen fixation, the enzyme nitrogenase mediates the reductive cleavage of the stable triple bond of gaseous N2at ambient conditions, driven by the hydrolysis of ATP, to yield bioavailable ammonium (NH4+). At the core of nitrogenase is a complex, ironsulfur based cofactor that in most variants of the enzyme contains an additional ...
Djurdjevic, Ivana +7 more
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Cofactor dependent and cofactor independent anticardiolipin antibodies
Thrombosis Research, 1991Two distinct types of anticardiolipin antibodies are described, one of which requires the presence of a serum factor (cofactor) to bind cardiolipin in ELISA and liposome affinity systems. The second type does not require this cofactor. The requirement of a cofactor for the binding of some but not all anticardiolipin antibodies provides an explanation ...
N. S. Pattison +2 more
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Novel cofactor derivatives and cofactor-based models
Current Opinion in Chemical Biology, 1998In 1997 and the first half of 1998, numerous publications appeared reporting studies of cofactors and their analogues in classical model systems and in enzyme-catalyzed reactions directed at understanding the enzymatic reactions of their natural cofactors. Model systems based on flavins have provided new insights into enzymatic modulation of the flavin
Dale G. Drueckhammer, Pranab Mishra
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2009
Cofactors are organic molecules, most of them originating from vitamins, that bind to enzymes making them able to catalyze defined reactions. A cofactor-based chemogenomics approach exploits the presence of a cofactor-binding domain to develop compound scaffolds tailored to mimic the cofactor and to replace it within target enzyme classes. As a result,
SINGH R, MOZZARELLI, Andrea
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Cofactors are organic molecules, most of them originating from vitamins, that bind to enzymes making them able to catalyze defined reactions. A cofactor-based chemogenomics approach exploits the presence of a cofactor-binding domain to develop compound scaffolds tailored to mimic the cofactor and to replace it within target enzyme classes. As a result,
SINGH R, MOZZARELLI, Andrea
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Evaluation of cofactor responsiveness
Journal of Inherited Metabolic Disease, 1985AbstractThe response to cofactor therapy in inborn errors of metabolism may be dramatic with complete resolution of the clinical illness but more commonly the response is absent or partial. When assessing cofactor responsiveness clinical and biochemical findings as well as the natural history of the disorder must be taken into account.
P. Daish, J. V. Leonard
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The Cofactor Pyrroloquinoline Quinone
Annual Review of Nutrition, 1990Article de synthese sur un cofacteur: la pyrroloquinoleine quinone. Etude de ses proprietes; caracteristiques, formes moleculaires, stabilite. Identification et analyse quantitative des formes libres, derivees et liees par liaison covalente. Distribution chez les procaryotes, les eucaryotes, les aliments et les boissons.
R. A. van der Meer +2 more
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1992
MCP serves to down-regulate the activation of complement on host tissue. It performs this function by serving as a cofactor for the factor I-mediated cleavage of C3b and C4b. MCP is most likely an intrinsic regulator, i.e., it primarily protects its home cell.
M K Liszewski, John P. Atkinson
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MCP serves to down-regulate the activation of complement on host tissue. It performs this function by serving as a cofactor for the factor I-mediated cleavage of C3b and C4b. MCP is most likely an intrinsic regulator, i.e., it primarily protects its home cell.
M K Liszewski, John P. Atkinson
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Heterogeneous Catalysis Mediated Cofactor NADH Regeneration for Enzymatic Reduction
, 2016Enzymatic reduction using oxidoreductases is important in commercial chemical production. This enzymatic action requires a cofactor (e.g., NADH) as a hydrogen source that is consumed during reaction and must be regenerated. We present, for the first time,
Xiaodong Wang, H. H. Yiu
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Surprising cofactors in metalloenzymes [PDF]
Current Opinion in Structural Biology, 2003 Transition metal complexes are located at the active sites of a number of enzymes involved in intriguing biochemical reactions. These complexes can exhibit a wide variety of chemical reactivity due to the ease at which transition metals can adopt different coordination environments and oxidation states. Crystallography has been a powerful technique for
John W. Peters, Catherine L. Drennan
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Engineering cofactor supply and recycling to drive phenolic acid biosynthesis in yeast
Nature Chemical Biology, 2022Ruibing Chen +7 more
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