Results 131 to 140 of about 32,161 (285)

Plato's Theory of Knowledge [PDF]

, 2018
An account of Plato’s theory of knowledge is offered. Plato is in a sense a contextualist: at least, he recognizes that his own use of the word for “knowledge” varies – in some contexts, it stands for the fullest possible level of understanding of a ...
Wedgwood, Ralph
core  

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Substituent‐Based Modulation of Self‐Assembly and Immunogenicity of Amphipathic Peptides

Advanced Science, EarlyView.
This study systematically investigates how positional and subtle changes, such as substituents on the phenyl ring attached to short amphipathic peptides, influence their self‐assembly, fibril morphology, and immunogenic responses. ABSTRACT Self‐assembled peptide‐based biomaterials provide versatile platforms for biomedical uses, featuring customizable ...
Anirban Das, Ushasi Pramanik, Elise M. Brown, Chih‐Yun Liu, Huan Gong, Jonathan Fascetti, Mark Gibson, Samuel Stealey, Silviya P. Zustiak, Cory Berkland, Piyoosh Sharma, Meredith E. Jackrel, Mark A. White, Jai S. Rudra   +13 more
wiley   +1 more source

Near-cognate tRNAs dominate codon decoding times in simulated ribosomes. [PDF]

Nucleic Acids Res
Hedayioglu F, Hargreaves EJ, Kurusamy S, Thaventhiran JED, Willis AE, Smales CM, von der Haar T.   +6 more
europepmc   +2 more sources

Enhanced Oxygen Redox Activity and Structure Stability of P2‐Type Manganese‐Based Cathodes Through Medium‐Entropy Strategy

Advanced Science, EarlyView.
A medium‐entropy strategy guided by ionic potential is applied to weaken TM─O bonds and suppress Jahn–Teller distortion in P2‐type cathodes, thereby enhancing the oxygen redox activity and structure stability. A medium‐entropy oxide, Na0.8Li0.1Ni0.1Cu0.1Ti0.1Mn0.6O2, demonstrates a high reversible capacity of 223.7 mAh g−1 and an energy density of 616 ...
Dongxiao Wang, Yuxuan Liu, Zihao Wang, Wei Su, Xingguo Qi, Huican Mao, Kan Zhang, Shigang Lu, Bingkun Guo, Yingchun Lyu   +9 more
wiley   +1 more source

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Visual word recognition of Chinese-Japanese bilinguals: limited role of phonology. [PDF]

Front Psychol, 2023
Jiao Z, Du L, Wang Y, Li Y.
europepmc   +1 more source

Notes and Communications: Iotization and Palatalization in Classical Tibetan [PDF]

, 1975
Boyce, Walter Simon
core   +1 more source

Parasitic Plant–Host Interactions: Molecular Mechanisms and Agricultural Resistance Strategies

Advanced Science, EarlyView.
Parasitic plants devastate global agriculture through sophisticated molecular interactions with host crops. This review synthesizes current understanding of parasitic plant‐host interactions, from strigolactone‐mediated germination and haustorium formation to host defense mechanisms.
Jiayang Shi, Qi Xie, Feifei Yu
wiley   +1 more source

Reaction Mechanism, Challenges, and Strategies of High‐Energy‐Density Sodium‐Ion Batteries

Advanced Science, EarlyView.
Focusing on high‐energy‐density sodium‐ion batteries, this review highlights the advantages offered by conversion‐type cathode materials. The currently studied cathode materials are systematically introduced. By analyzing sulfur, oxygen, and transition metal halides and other conversion‐type cathodes, the key challenges associated with these cathodes ...
Dan Yu, Yuxin Cui, Qinghao Chen, Lu Gao, Xia Liu, Tianci Li, Wenju Zhu, Quanxiang Li, Weimin Kang   +8 more
wiley   +1 more source