Results 121 to 130 of about 2,085,476 (385)
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
The relationship between trait curiosity and cognitive reserve in younger and older adults
Scientific ReportsUnderstanding individual differences in cognitive reserve is key to predicting, and potentially influencing, factors that promote healthy cognitive aging.
Iris Wiegand +5 more
doaj +1 more source
Distributed Processes, Distributed Cognizers and Collaborative Cognition
, 2005 Cognition is thinking; it feels like something to think, and only those who can feel can think. There are also things that thinkers can do. We know neither how thinkers can think nor how they are able do what they can do.
Harnad, Stevan
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A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Scientific DataThe SpiderPhy dataset is a dataset of physiological, psychometric, and behavioral data from subclinical spider fearful individuals (N = 54) who underwent exposure to spider stimuli.
Cindy S. Lor +9 more
doaj +1 more source
Cognitive Reserve? Cognitive Capacity!
Brain SciencesThe concept of cognitive reserve (CR) has been a cornerstone in cognitive aging research, offering a framework to explain how life experiences like education, occupation, bilingualism, and physical exercise may buffer individuals from cognitive decline in the face of aging or neurological disease.
openaire +3 more sources
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
CURRICULUM, COGNITION, AND EDUCATIONAL MEASUREMENT1 [PDF]
, 1963 Robert W. Heath
openalex +1 more source
Cognition simulation and learning [PDF]
, 1980 The purpose of this paper is to describe new computer software that has been specifically developed to aid experiential learning in groups and with individuals.
Eden, Colin +2 more
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