Results 121 to 130 of about 1,827,224 (341)

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

The relationship between trait curiosity and cognitive reserve in younger and older adults

open access: yesScientific Reports
Understanding individual differences in cognitive reserve is key to predicting, and potentially influencing, factors that promote healthy cognitive aging.
Iris Wiegand   +5 more
doaj   +1 more source

Mnemonic convergence in the human hippocampus

open access: yesNature Communications, 2016
The ability to form associations between events is the hallmark of episodic memory and is thought to involve the hippocampus. Here the authors use a combination of multivariate pattern and graph theoretical network analyses of functional imaging data in ...
Alexander R. Backus   +4 more
doaj   +1 more source

A framework for Thinking about Distributed Cognition [PDF]

open access: yes, 2006
As is often the case when scientific or engineering fields emerge, new concepts are forged or old ones are adapted. When this happens, various arguments rage over what ultimately turns out to be conceptual misunderstandings.
Chicoisne, Guillaume, Poirier, Pierre
core  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

SpiderPhy dataset: A multimodal dataset of Physiological, Psychometric and Behavioral Responses to fear stimuli

open access: yesScientific Data
The SpiderPhy dataset is a dataset of physiological, psychometric, and behavioral data from subclinical spider fearful individuals (N = 54) who underwent exposure to spider stimuli.
Cindy S. Lor   +9 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

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