Results 141 to 150 of about 2,005,242 (383)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Construction and Cognition

THEORIA, 2009
The Structure of Appearance presents a phenomenalist system which constructs enduring visible objects out of qualia. Nevertheless Goodman does not espouse phenomenalism. Why not? In answering this question this paper explicates Goodman's views about the nature and functions of constructional systems, the prospects of reductionism, and the character of
openaire   +4 more sources

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

“R” you getting this? Factors contributing to the public’s understanding, evaluation, and use of basic reproduction numbers for infectious diseases

BMC Public Health
Background We (1) examined the effects of evaluative labels and visual aids on people’s understanding, evaluation, and use of the COVID-19 reproduction number (or “r-number”), (2) examined whether people’s perceived susceptibility and (intended ...
Ruben D. Vromans, Nadine Bol, Marloes M. C. van Wezel, Emiel J. Krahmer   +3 more
doaj   +1 more source

THE IMPACT OF NEGATIVE AFFECT ON COGNITION AND PERSONALITY1 [PDF]

, 1965
Samuel Messick
openalex   +1 more source

Cognitive Reserve? Cognitive Capacity!

Brain Sciences
The concept of cognitive reserve (CR) has been a cornerstone in cognitive aging research, offering a framework to explain how life experiences like education, occupation, bilingualism, and physical exercise may buffer individuals from cognitive decline in the face of aging or neurological disease.
openaire   +3 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Author Correction: Oscillatory dynamics underlying noun and verb production in highly proficient bilinguals

Scientific Reports, 2023
Shuang Geng, Nicola Molinaro, Polina Timofeeva, Ileana Quiñones, Manuel Carreiras, Lucia Amoruso   +5 more
doaj   +1 more source

Cortical representations of affective pain shape empathic fear in male mice

Nature Communications
Affect sharing, the ability to vicariously feel others’ emotions, constitutes the primary component of empathy. However, the neural basis for encoding others’ distress and representing shared affective experiences remains poorly understood.
Jiye Choi, Young-Beom Lee, Dahm So, Jee Yeon Kim, Sungjoon Choi, Sowon Kim, Sehoon Keum   +6 more
doaj   +1 more source

CURRICULUM, COGNITION, AND EDUCATIONAL MEASUREMENT1 [PDF]

, 1963
Robert W. Heath
openalex   +1 more source