Results 51 to 60 of about 5,782,571 (261)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Speech pauses facilitate older adults’ comprehension of complex sentences: an EEG study on Chinese garden-path sentence processing

Language and Cognition
Age-related syntactic processing abilities are not only associated with linguistic competence in later life but also reflect cognitive decline progression.
Jiaxuan Chen, Xuanshu Chen, Yuyao Mao, Yujie Mu, Xindi Pan, Shiwen Feng   +5 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Social and Cognitive Impressions of Adults Who Do and Do Not Stutter Based on Listeners' Perceptions of Read-Speech Samples

Frontiers in Psychology, 2017
Stuttering is a neurodevelopmental disorder characterized by frequent and involuntary disruptions during speech production. Adults who stutter are often subject to negative perceptions.
Lauren J. Amick, Soo-Eun Chang, Juli Wade, J. Devin McAuley   +3 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Inequality, Education, Workforce Preparedness, and Complex Problem Solving

Journal of Intelligence, 2018
Economic inequality has been described as the defining challenge of our time, responsible for a host of potential negative societal and individual outcomes including reduced opportunity, decreased health and life expectancy, and the destabilization of ...
Patrick C. Kyllonen
doaj   +1 more source

Intergenerational continuity and discontinuity in cognitive ability: the first offspring of the British 1946 birth cohort [PDF]

, 2009
Cognitive development in childhood is a key factor affecting adult life chances, including educational and occupational success. Intergenerational continuity in cognitive ability is often observed.
Byford, M.
core  

Genetic covariation among facets of openness to experience and general cognitive ability [PDF]

, 2008
Genetic and environmental sources of covariation among cognitive measures of verbal IQ, performance IQ (PIQ), academic achievement, 2-choice reaction time (CRT), inspection time (IT) and the 6 Openness facets of the NEO Personality Inventory-Revised (NEO
Wright, Margaret J., Luciano, Michelle, Wainwright, Mark A, Geffen, Gina M, Wright, Margaret J, Geffen, Gina M., Martin, Nicholas G., Wainwright, Mark A., Martin, Nicholas G   +8 more
core   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source