Results 101 to 110 of about 2,225,872 (200)

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Travel choices in Scotland - the effect of local accessibility on non-work travel [PDF]

, 2005
Accessibility features prominently in the developing transport policies of both the United Kingdom Government and the devolved Scottish Executive which aim to promote social inclusion in particular and the integration of transport and land use planning ...
Ferguson, N.S., Carreno, M., Stradling, S.   +2 more
core  

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Enhancing Accessibility, Engagement, and Motivation in Counseling Services for Secondary Schools through Gamified Blended Mobile and Virtual Reality Therapy

Intensif: Jurnal Ilmiah Penelitian Teknologi dan Penerapan Sistem Informasi
Background: Secondary school counseling services often face challenges such as limited counselor availability and low student participation. Traditional counseling methods frequently fail to engage students, thus reducing both accessibility and impact ...
Putri Taqwa Prasetyaningrum, Norshahila Ibrahim, Eka Aryani, Rully Ningsih, Ibnu Rivansyah Subagyo   +4 more
doaj   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Attitudes Toward Surveys, Attitude Accessibility and the Effect on Respondents� Susceptibility to Nonresponse [PDF]

This paper analyzes whether respondents attitudes toward surveys explains their susceptibility to item nonresponse. In contrast to previous studies, the decision to refuse to provide income information, not to answer other questions and the probability ...
Stocké, Volker
core  

Sex‐Stratified Association of Regional Dopamine Transporter Binding With Disease Progression in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To clarify the clinical relevance of dopamine transporter single‐photon emission computed tomography (DAT‐SPECT) abnormalities in amyotrophic lateral sclerosis (ALS), with a prespecified focus on sex‐stratified associations with disease progression and short‐term prognosis.
Tomoya Kawazoe, Keizo Sugaya, Kentaro Hayashi, Keiko Hino, Yasuhiro Nakata, Kota Bokuda, Toshio Shimizu, Kazushi Takahashi   +7 more
wiley   +1 more source

Cognitive accessibility online

, 2019
Since the start of 2019 a new law has been introduced in Sweden, it serves to regulate web accessibility conformity for all publicly funded organisations. At the same time, many services and businesses move their physical fronts to the web.
Jensen, Martin, Ross, Mattias
core   +2 more sources

Exploring Web Accessibility and Usability for Users with Attention Deficit Hyperactivity Disorder: Evaluation of Specific Guidelines and Adaptations

International Journal of Interactive Multimedia and Artificial Intelligence
Attention Deficit Hyperactivity Disorder (ADHD) presents specific cognitive and attentional characteristics that can significantly affect web navigation and information processing.
Lucía Alonso Virgós, Isabel Morales Gil, Luis Rodriguez Baena, Jordán Pascual Espada, Rubén González Crespo   +4 more
doaj   +1 more source

White Matter Microstructural Abnormalities in Neonatal Onset Genetic Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Recent evidence indicates that epilepsy is associated with abnormal white matter. If seizures alter white matter, then the impact upon network function, epileptogenesis, and cognition could be pronounced in neonates undergoing rapid developmental myelination. Neonates with epilepsy due to nonstructural genetic causes provide a unique
Amanda G. Sandoval Karamian, Tianjia Zhu, Hao Huang, Shavonne L. Massey, Mark P. Fitzgerald, Darshana Parikh, Arastoo Vossough, Ingo Helbig, Nicholas S. Abend   +8 more
wiley   +1 more source