Results 101 to 110 of about 4,029,695 (306)

Dopamine release plateau and outcome signals in dorsal striatum contrast with classic reinforcement learning formulations

Nature Communications
We recorded dopamine release signals in centromedial and centrolateral sectors of the striatum as mice learned consecutive versions of visual cue-outcome conditioning tasks. Dopamine release responses differed for the centromedial and centrolateral sites.
Min Jung Kim, Daniel J. Gibson, Dan Hu, Tomoko Yoshida, Emily Hueske, Ayano Matsushima, Ara Mahar, Cynthia J. Schofield, Patlapa Sompolpong, Kathy T. Tran, Lin Tian, Ann M. Graybiel   +11 more
doaj   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

Resting state cortical EEG rhythms in Alzheimer's disease: toward EEG markers for clinical applications: a review [PDF]

, 2012
The human brain contains an intricate network of about 100 billion neurons. Aging of the brain is characterized by a combination of synaptic pruning, loss of cortico-cortical connections, and neuronal apoptosis that provoke an age-dependent decline of ...
Lizio, Roberta, De Vico Fallani, Fabrizio, Fabrizio Vecchio, F. De Vico Fallani, Frisoni, Giovanni, Fabrizio De Vico Fallani, Giulio Verrienti, Giovanni Frisoni, Vecchio, Fabrizio, Rossini, Paolo M, G. Verrienti, P. M. Rossini, F. Vecchio, Verrienti, Giulio, Frisoni, Giovanni B., Paolo M. Rossini, Rossini, Paolo M., Babiloni, Claudio, Fde V. Fallani, Blinowska, Katarzyna, G. Frisoni, Rossini, Paolo Maria, Claudio Babiloni, K. Blinowska, Katarzyna Blinowska, Roberta Lizio   +25 more
core   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Spatiotemporal dynamics of argument retrieval and reordering: an fMRI and EEG study on sentence processing

Frontiers in Psychology, 2012
In sentence processing, it is still unclear how the neural language network successfully establishes argument–verb dependencies in its spatiotemporal neuronal dynamics.
Lars eMeyer, Jonas eObleser, Stefan J Kiebel, Angela Dorkas Friederici   +3 more
doaj   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Communicative competence and the architecture of the mind/brain

, 1999
Cognitive pragmatics is concerned with the mental processes involved in intentional communication. I discuss a few issues that may help clarify the relationship between this area and the broader cognitive science and the contribution that they give, or ...
Maurizio Tirassa, Tirassa, Maurizio
core  

Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon, Hugues Chabriat, Dominique Hervé, Stéphanie Guey, Sophie Tezenas Du Montcel, Juliette Ortholand   +5 more
wiley   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Cognitive and mood effects in healthy children during 12 weeks' supplementation with multi-vitamin/minerals [PDF]

, 2008
Adequate levels of vitamins and minerals are essential for optimal neural functioning. A high proportion of individuals, including children, suffer from deficiencies in one or more vitamins or minerals.
Kennedy, David O, Jackson, Philippa A, Robertson, Bernadette C, Defeyter, M.A., Greer, Joanna, Scholey, Andrew B, Jackson, Philippa, Jackson, P.A., Robertson, B.C., Buchanan, Tom, Scholey, Andrew, Haskell, Crystal F, Defeyter, Margaret Anne (Greta), Haskell, C.F., Kennedy, D.O., Scholey, A.B., Elliott, J.M., Tiplady, B., Defeyter, Margaret A, Haskell, Crystal, Kennedy, David, Elliott, Jade, Robertson, Bernadette, Buchanan, T., Tiplady, Brian, Greer, J., Elliott, Jade M   +26 more
core   +1 more source