Results 61 to 70 of about 3,318,890 (283)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Development of LKPD through Cognitive Conflict Strategy Learning Assisted with Augmented Reality to Improve Mathematical Problem Solving Capability

Ideguru
This research aims to analyzing the validity, practicality and effectiveness of students' worksheets through cognitive conflict strategies to improve mathematical problem-solving abilities through learning cognitive conflict strategies assisted by ...
Rusmini Rusmini, Elmanani Simamora, Mulyono Mulyono, Dian Armanto, Muktar Muktar   +4 more
doaj   +1 more source

Effect of Cognitive Conflict Strategies on Students' Cognitive Learning Outcomes

Jurnal Penelitian Pendidikan IPA, 2022
An important aspect of learning outcomes at all levels of education is cognitive learning outcomes, and to achieve optimal cognitive learning outcomes, multi-method intervention is needed. This study aims to determine the effect of using cognitive conflict strategies on students' cognitive learning outcomes. Experimental research with one group pretest-
Widia, Widia, Suhirman, Suhirman, Suhardi, Muhammad, Prayogi, Saiful, Yamin, Muhammad, Salahuddin, Muhammad, Haryanto, Lutfin, Ewisahrani, Ewisahrani, E Nursa’ban, E Nursa’ban, Ilyas, Ilyas, Mujitahid, Mujitahid   +10 more
openaire   +2 more sources

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Pengembangan Bahan Ajar Konsep Diferensial Berbasis Konflik Kognitif

Jurnal Elemen, 2018
The purpose of this study is to assess the validity and practicality of teaching materials in the form of RPP and LKS. This type of research is research and development (R & D) with the design of teaching materials (prototype), interview guides (in ...
Wahyu Setiawan, Veny Triyana Andika Sari
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Conflict and the Cognitive Empire: [PDF]

, 2022
No abstract available.
openaire   +1 more source

Post-conflict slowing: cognitive adaptation after conflict processing [PDF]

Psychonomic Bulletin & Review, 2010
The aftereffects of error and conflict (i.e., stimulus or response incongruency) have been extensively studied in the cognitive control literature. Each has been characterized by its own behavioral signature on the following trial. Conflict leads to a reduced congruency effect (Gratton effect), whereas an error leads to increased response time (post ...
Tom, Verguts, Wim, Notebaert, Wilfried, Kunde, Peter, Wühr   +3 more
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

PERAN KONFLIK KOGNITIF DAN AFEKTIF PADA IMPLEMENTASI ACTIVITY BASED COST MANAJEMENT PADA PERUSAHAAN MANUFAKTUR DI JAWA TENGAH

Jurnal Analisis Bisnis Ekonomi, 2017
Review the key factors on the success of the implementation of ABCM associated with the support of top management, clearly goals, and training. Conflicts tend to appear during the implementation of ABCM.
Supartini Supartini
doaj