Results 111 to 120 of about 989,086 (340)

Frailty Exacerbates Disability in Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background To evaluate frailty in severe progressive multiple sclerosis (PMS) and to investigate the underlying mechanisms. Methods This prospective, cross‐sectional, multicenter study enrolled a late severe PMS group requiring skilled nursing (n = 53) and an age, sex, and disease duration‐matched control PMS group (n = 53).
Taylor R. Wicks, Anna Wolska, Diala Ghazal, Dejan Jakimovski, Bianca Weinstock‐Guttman, Alexander Burnham, Niels Bergsland, Michael G. Dwyer, Alan T. Remaley, Robert Zivadinov, Murali Ramanathan   +10 more
wiley   +1 more source

Microgravity-induced Cognitive Decline

Hanggong uju uihakoeji
Microgravity-induced cognitive decline is recognized as a critical challenge to reduce performance during space exploration by leading to impairments in problem-solving ability, memory, judgment, emotion regulation, and even personality.
Gyutae Kim, Kyu-Sung Kim
doaj   +1 more source

Modelling the relationship between visual short-term memory capacity and recall ability [PDF]

, 2008
Previous cognitive modelling work has suggested that the decline of short-term memory (STM) capacity is the dominant factor of age-related decline on recall ability. We report the results of a set of experiments investigating in further detail the effect
Gobet, F, Lane, PCR, Smith, RL
core   +1 more source

Dorsolateral Cervical Cord T2 Hyperintensity in KIF1C‐Related Disease (Spastic Paraplegia 58): Two Long‐Duration Cases

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Pathogenic variants in KIF1C cause Spastic Paraplegia 58 (SPG58), typically presenting with cerebellar ataxia and spastic paraparesis. We report two unrelated patients with spastic paraparesis, cerebellar ataxia, and tremor. Whole‐exome sequence analysis identified novel homozygous variants in the motor domain of KIF1C (NM_006612.6): c.921G>A (
Akihiko Mitsutake, Masao Osaki, Takashi Matsukawa, Miho Osako, Chisen Takeuchi, Hiroyuki Ishiura, Jun Mitsui, Ryo Kurokawa, Harushi Mori, Yuji Takahashi, Jun Goto, Shoji Tsuji, Tatsushi Toda   +12 more
wiley   +1 more source

Advances in the Study of Sleep-related Subjective Cognitive Decline [PDF]

Zhongguo quanke yixue
Subjective cognitive decline (SCD) usually predicts the risk of future cognitive decline, and sleep disturbances are very common in patients with SCD and often precede detectable cognitive changes.
WEN Yining, HUANG Huichang, ZHAO Mingming
doaj   +1 more source

Impact of flavonoids on cellular and molecular mechanisms underlying age-related cognitive decline and neurodegeneration [PDF]

, 2018
Purpose of Review: This review summarises the most recent evidence regarding the effects of dietary flavonoids on age-related cognitive decline and neurodegenerative diseases.
Flanagan, Emma, Hornberger, Michael, Müller, Michael, Vauzour, David   +3 more
core   +1 more source

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

Analysis of cognitive function trajectories and influencing factors in elderly patients with ischemic stroke: a prospective longitudinal study

Frontiers in Aging Neuroscience
Background and purposeAccurately defining cognitive function trajectories in elderly ischemic stroke patients is crucial for identifying high-risk groups for cognitive decline, enabling timely personalized interventions to improve long-term outcomes and ...
Xinhao Chen, Chengxia Wei, Danli Zhao, Chenmei Zhou, Wenjing Wang, Gendi Lu, Gendi Lu   +6 more
doaj   +1 more source

Cardiovascular genetic asseaCardiovascular genetic assessment and treatment in middle age to reduce the risk of heart disease and dementia in old agesment and treatment in middle age to reduce the risk of heart disease and dementia in old age

South African Family Practice, 2006
Assessment and treatment of cardiovascular disease (CVD) risk factors as a preventable cause of cognitive decline, morbidity and mortality is an important clinical goal.
M.J. Kotze, R. Thiart, F.J. Hugo, F.C.W. Potocnik   +3 more
doaj   +1 more source

SENSORY AND MOTOR FUNCTIONS IMPROVE LONG-TERM PREDICTIONS OF NEURODEGENERATION AND COGNITIVE DECLINE

, 2023
Natascha Merten, Adam J. Paulsen, Richard J. Chappell, Yanjun Chen, Luigi Ferrucci, Laura M. Hancock, Sterling C. Johnson, Carla R. Schubert   +7 more
openalex   +1 more source