Results 231 to 240 of about 965,316 (341)

Engineering Aging: Approaches to Model and Deconstruct Biological Complexity

Advanced Materials, EarlyView.
The macro‐experiences of aging are the result of an accumulation of micro‐changes that occur over time. Abstract The disparity between the global increase in life expectancy and the steady decline in health outcomes with age has been a major driver for developing new ways to research aging.
Habib Joukhdar, Sunny Shinchen Lee, Thomas R. Cox, Yu Suk Choi, Steven G. Wise, Jennifer L. Young, Giselle C. Yeo, Khoon S. Lim   +7 more
wiley   +1 more source

U-shaped association of resting heart rate with cognitive decline. [PDF]

Brain Commun
Tan ESJ, Sim MA, Li L, Toh A, Chong EJY, Chan SP, Kan CN, Tan XT, Cui J, Hilal S, Chong JR, Lai MKP, Venketasubramanian N, Tan BY, Richards AM, Ling LH, Chen CLH.   +16 more
europepmc   +1 more source

An increased rate of longitudinal cognitive decline is observed in Parkinson's disease patients with low CSF Aß42 and an APOE ε4 allele

, 2019
Marian Shahid, Jeehyun Kim, Katherine Leaver, Taylor R. Hendershott, Delphine Zhu, Brenna Cholerton, Victor W. Henderson, Lü Tian, Kathleen L. Poston   +8 more
openalex   +2 more sources

Neuroimmune Microenvironment Reprogramming via Immuno‐piezoelectric Transducers for Synergistic Stem Cell Therapy in Traumatic Brain Injury

Advanced Materials, EarlyView.
A novel immuno‐piezoelectric transducer is innovatively developed. This device promotes neural stem cell (NSC) differentiation and maturation via ultrasound‐induced electrical stimulation and it amplifies the therapeutic efficacy of NSC in traumatic brain injury (TBI) by modulating the immune microenvironment. This piezoelectric transducer with “immune‐
Linlin Liang, Xin Li, Kai Hu, Pingqiang Cai, Jianwu Wang, Jing Yu, Shasha Wang, Yuwei Zhao, Changgeng Xu, Siwei Li, Hong Liu, Changyong Wang, Jin Zhou   +12 more
wiley   +1 more source

Linguistic Markers in Spontaneous Speech: Insights into Subjective Cognitive Decline (Review). [PDF]

Healthcare (Basel)
Segkouli S, Gkioka M, Kokkas S, Votis K, Valero S, Miguel A, Antoniades A, Charalambous E, Manias G.   +8 more
europepmc   +1 more source

Lithium‐Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity

Advanced Materials, EarlyView.
This study introduces glutathione‐stabilized gold nanoparticles for targeted lithium delivery (LiG‐AuNPs), enabling the controlled modulation of Glycogen Synthase Kinase‐3 (GSK‐3β). These non‐toxic, 2‐nm particles release lithium intracellularly, effectively inhibiting GSK‐3β in the brain without significant plasma lithium alterations.
Antonio Buonerba, Giulia Puliatti, Domenica Donatella Li Puma, Bruno Bandiera, Beatrice Cannata, Maria Elena Marcocci, Nicolina Castagno, Irene Contento, Salvatore Impemba, Mariarosa Scognamiglio, Rocco Di Girolamo, Vincenzo Naddeo, Patrizia Canton, Carmine Capacchione, Laura Sposito, Martina Albini, Francesco Pastore, Silvia Baroni, Alfonso Grassi, Claudio Grassi, Roberto Piacentini   +20 more
wiley   +1 more source

CSF proteomic profiles related to cognitive decline in MCI A+ depend on tau levels. [PDF]

Brain
Vromen EM, de Leeuw DM, van Harten AC, Teunissen CE, van der Flier WM, Visser PJ, Tijms BM.   +6 more
europepmc   +1 more source

Macrophages Mediate Mesoscale Brain Mechanical Homeostasis

Advanced Materials, EarlyView.
We investigated the role of infiltrating immune cells in sculpting the developing brain. Using Brillouin microscopy and active microrheology, we found microglia actively maintain tissue viscoelasticity. Moreover, colony stimulating factor one receptor (CSF1R)‐driven stromal remodeling alters brain mechanics in vivo. These findings link immune activity,
Woong Young So, Bailey Johnson, Patricia B. Gordon, Kevin S. Bishop, Hyeyeon Gong, Hannah A Burr, Jack Rory Staunton, Chenchen Handler, Khanh Loan Ly, Raman Sood, Giuliano Scarcelli, Kandice Tanner   +11 more
wiley   +1 more source

Blood biomarkers of Alzheimer's disease and progression across different stages of cognitive decline in the community. [PDF]

Nat Commun
Valletta M, Vetrano DL, Gregorio C, Rizzuto D, Winblad B, Canevelli M, Andersson S, Dale M, Fredolini C, Laukka EJ, Fratiglioni L, Grande G.   +11 more
europepmc   +1 more source

Recent Progress in Memristor Array‐Based Neuromorphic Computing for on‐Chip Vector‐Matrix Multiplication

Advanced Materials Technologies, EarlyView.
Recent efforts of memristor array‐based hardware neuromorphic computing are discussed for efficient application of VMM on‐chip level in terms of circuit integration and actual application of AI algorithms. The parallel data processing principle of VMM operation is briefly reviewed, and hardware VMM is presented including convolutional transformation ...
Jingon Jang, Sang‐gyun Gi
wiley   +1 more source