Results 241 to 250 of about 3,032,817 (338)

Cognitive modelling of economic development of industrial ecosystems

open access: diamond
E.S. Mityakov   +3 more
openalex   +1 more source

Lithium‐Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity

open access: yesAdvanced Materials, EarlyView.
This study introduces glutathione‐stabilized gold nanoparticles for targeted lithium delivery (LiG‐AuNPs), enabling the controlled modulation of Glycogen Synthase Kinase‐3 (GSK‐3β). These non‐toxic, 2‐nm particles release lithium intracellularly, effectively inhibiting GSK‐3β in the brain without significant plasma lithium alterations.
Antonio Buonerba   +20 more
wiley   +1 more source

Macrophages Mediate Mesoscale Brain Mechanical Homeostasis

open access: yesAdvanced Materials, EarlyView.
We investigated the role of infiltrating immune cells in sculpting the developing brain. Using Brillouin microscopy and active microrheology, we found microglia actively maintain tissue viscoelasticity. Moreover, colony stimulating factor one receptor (CSF1R)‐driven stromal remodeling alters brain mechanics in vivo. These findings link immune activity,
Woong Young So   +11 more
wiley   +1 more source

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

open access: yesAdvanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode   +16 more
wiley   +1 more source

Aqueously Upcycled Lignin with Emergent Tribonegativity for Skin‐Integrated Triboelectronics

open access: yesAdvanced Materials, EarlyView.
Aqueously upcycled lignin is transformed into a printable ink that self‐assembles into a nanotextured surface during printing with the highest reported biopolymer‐based tribonegativity. The resulting skin‐integrated triboelectric sensor enables high‐fidelity cardiovascular monitoring and objective mental workload classification, demonstrating a ...
Robert Ccorahua‐Santo   +3 more
wiley   +1 more source

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