Results 41 to 50 of about 823,624 (312)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cognitive behavior therapy in panic disorder and comorbid major depression - A naturalistic study [PDF]

, 2000
Background: There is a lack of evidence about the effectiveness of cognitive behavior therapies (CBT) in settings of routine clinical care as well as in the treatment of panic and comorbid disorders. Methods: We investigated a group-oriented CBT approach
Fichter, Manfred M., Trenkamp, Susanne, Rief, Winfried, Auer, Claudia   +3 more
core   +1 more source

Proteomic analysis in Alzheimer’s disease and other dementias: a focus on sex-specific differences

Alzheimer’s Research & Therapy
Background Fluid protein studies in cerebrospinal fluid (CSF) and plasma have provided important insights into neurodegenerative dementias; however, there is a limited investigation of sex-related differences and cross-biofluid relationships.
Aina Comas-Albertí, Albert Lladó, Diana Esteller-Gauxax, Sergi Borrego-Écija, Neus Falgàs, Farida Dakterzada, Agnès Pérez-Millan, Roger Puey, Tània Collet-Romà, Núria Guillén, Miquel Massons, Adrià Tort-Merino, Josep Maria Augé, Guadalupe Fernandez-Villullas, Bea Bosch, Raquel Ruiz-García, Laura Naranjo, Mircea Balasa, Gerard Piñol-Ripoll, Anna Antonell, Raquel Sánchez-Valle   +20 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Oxidative stress in neurodegeneration: from a simple insult to a dynamic regulator

Redox Report
Objectives To evaluate the central role of oxidative stress in neurodegenerative diseases, and to explore its dynamic regulatory features, underlying signaling pathways, and molecular mechanisms, as well as advanced technological strategies for ...
Lan Zhang, Xinyue Zhai, Yalong Yan, Lihong Xiang, Yue Zhang, Xinying Zhou, Lianmei Cai, Zixi Tang, Yiyuan Xia   +8 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Is Serum Progranulin Level a Biomarker in Autism and Cognitive Development Disorders?

, 2022
Objective: Cognitive developmental delay is a picture of the group of early-onset chronic diseases that affect 1.5-10% of children. Autism spectrum disorders are neurodevelopmental diseases with a genetic basis and abnormal brain development ...
Atilla Cayir, Kurt, Nezahat, Ilknur Ibili Ucuz, Kubra Kocak Yilmaz, ÖZGERİŞ, FATMA BETÜL, Onur Burak Dursun, Mevlut Sait Keles, Betül Özgeriş, Fatma, Fatma Betul Ozgeris, Çayir, Atilla, Sait Keleş, Mevlüt, Ibili Ucuz, Ilknur, Burak Dursun, Onur, UCUZ, İLKNUR, Nezahat Kurt, DURSUN, ONUR BURAK, Koçak Yilmaz, Kübra, KELEŞ, MEVLÜT SAİT   +17 more
core   +1 more source

Disorders of Visuo-spatial Cognition

Neurocase, 2005
Disorders of visuo-spatial ...
Humphreys, G, Husain, M, Farné, A, Rorden, C, Bartolomeo, Paolo   +4 more
openaire   +3 more sources