Results 141 to 150 of about 339,240 (318)

Head injury: cognitive dysfunction

open access: yesActa Médica del Centro, 2012
A descriptive study was conducted in order to identify cognitive impairments in patients with head injuries and damage to the frontal lobes, features that appear more frequently as a consequence of these impairments.
Alfredo Amado Donéstevez de Mendaro   +2 more
doaj  

Extravasation of Borrelia burgdorferi Across the Blood–Brain Barrier is an Extremely Rare Event

open access: yesAdvanced Science, EarlyView.
Lyme disease is caused by vascular dissemination of the bacteria Borrelia. In a 3D tissue‐engineered microvessel model, Borrelia extravasation across the blood–brain barrier is extremely rare, implying that neuroborreliosis is not caused via direct cytotoxicity.
Linus Wang   +6 more
wiley   +1 more source

A clinical study on cognitive dysfunction in depressed patients

open access: yesIndustrial Psychiatry Journal
Background: Major depression is a commonly occuring, seriously impairing, and often recurrent mental disorder. Depression and cognitive impairement have enormous implications for public health.
Karnik Kishore, Deepanjali Medhi
doaj   +1 more source

Cognitive or cosmetic dysfunction? [PDF]

open access: yesArthritis & Rheumatism, 2012
Michael D. Lockshin   +2 more
openaire   +3 more sources

Role of Testosterone Signaling in Microglia: A Potential Role for Sex‐Related Differences in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
Testosterone enhances Aβ‐induced autophagy in microglia via the non‐genomic testosterone receptor GPRC6A, promoting Aβ clearance by suppressing ERK phosphorylation and inhibiting mTOR activation. In male 5xFAD mice, testicular removal reduces microglial autophagy and Aβ clearance, which is restored by testosterone.
Haiyan Du   +8 more
wiley   +1 more source

PERIOPERATIVE MONITORING WITH PULSE OXIMETRY AND LATE POSTOPERATIVE COGNITIVE DYSFUNCTION

open access: bronze, 1993
Jørn Møller   +8 more
openalex   +1 more source

Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

open access: yesAdvanced Science, EarlyView.
Arf1 defects activate the AKT‐mTORC1‐SREBP1‐FASN pathway to increase lipid synthesis and disrupt ER‐mitochondrial‐lysosomal homeostasis in neurons. Impaired mitochondria secrete damaged mtDNA via mitochondria‐derived extracellular vesicles, which is phagocytosed by the microglia and activated inflammation signaling.
Xu Li   +10 more
wiley   +1 more source

Advances in the pathogenesis of Rett syndrome using cell models

open access: yesAnimal Models and Experimental Medicine, Volume 5, Issue 6, Page 532-541, December 2022., 2022
Most Rett syndrome (RTT) patients are affected by the MECP2 gene mutations. And the mutations of MECP2 have wide effects on different cell types of nervous system, including neurons, astrocytes, oligodendrocytes and microglia, which always combined together to lead to abnormalities in the whole neural network.
Sijia Lu, Yongchang Chen, Zhengbo Wang
wiley   +1 more source

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