Results 191 to 200 of about 230,676 (213)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

open access: yesAdvanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao   +7 more
wiley   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

open access: yesAdvanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu   +19 more
wiley   +1 more source
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Conscious cognitive effort in cognitive control

Wiley Interdisciplinary Reviews: Cognitive Science, 2023
Joshua Shepherd
exaly  

Rewarding cognitive effort increases the intrinsic value of mental labor

Proceedings of the National Academy of Sciences of the United States of America, 2022
Georgia Clay   +2 more
exaly  

Effort Foraging Task reveals positive correlation between individual differences in the cost of cognitive and physical effort in humans

Proceedings of the National Academy of Sciences of the United States of America, 2023
Laura A Bustamante   +2 more
exaly  

Causal role of frontal-midline theta in cognitive effort: a pilot study

Journal of Neurophysiology, 2021
Amber Mcferren   +2 more
exaly  

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