Results 71 to 80 of about 2,811,639 (287)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Online Games Training Aging Brains:Limited transfer to cognitive control functions

Frontiers in Human Neuroscience, 2012
The prevalence of age-related cognitive decline will increase due to graying of the global population. The goal of the present study was to test whether playing online cognitive training games can improve cognitive control (CC) in healthy older adults ...
Jesse eVan Muijden, Guido P H Band, Bernhard eHommel   +2 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Well-designed manufacturing work improves some cognitive abilities in individuals with cognitive impairments

Frontiers in Rehabilitation Sciences
IntroductionEmployment is recognized as a fundamental human right, which correlates with better physical and mental health. Importantly, well-designed work, which considers the physical, social, and psychological impacts of work, can serve to enhance the
Pamela Banta Lavenex, Marie-Laure Blandin, Caroline Gaborieau, Pierre Lavenex   +3 more
doaj   +1 more source

Cognitive-enhancing drugs in the healthy population: Fundamental drawbacks and researcher roles

Cogent Psychology, 2015
The use of pharmacological cognitive enhancers (PCEs) in the healthy population is a controversial topic with numerous and expansive repercussions. By outlining common proponent arguments on the current PCE state of affairs, the definition of normality ...
Tsee Leng Choy
doaj   +1 more source

Editorial: Neurostimulation: exploring perceptual & cognitive enhancement [PDF]

Editorial on the Research Topic: Neurostimulation: exploring perceptual & cognitive ...
Campbell, MJ, Toth, AJ, Bruton, AM
core   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

KIT-13, a novel plasmalogen derivative, attenuates neuroinflammation and amplifies cognition

Frontiers in Cell and Developmental Biology
Plasmalogens (Pls) are specialized phospholipids integral to brain health, whose decline due to aging and stress contributes to cognitive impairment and neuroinflammation. This study explores the potential of a novel Pls derivative, KIT-13 (1-O-octadecyl-
Md Shamim Hossain, Shiro Mawatari, Masanori Honsho, Tatsuo Okauchi, Takehiko Fujino   +4 more
doaj   +1 more source

Critical Neuroscience – or Critical Science? A Perspective on the Perceived Normative Significance of Neuroscience

Frontiers in Human Neuroscience, 2014
Members of the Critical Neuroscience initiative raised the question whether the perceived normative significance of neuroscience is justified by the discipline’s actual possibilities.
Stephan eSchleim, Stephan eSchleim
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source