Results 11 to 20 of about 1,889,833 (35)

Cognitive enhancers for anxiety disorders

, 2011
Item does not contain fulltextCognitive-behavioral therapy is an effective intervention for anxiety disorders. However, a significant number of people do not respond or only show partial response even after an adequate course of the treatment.
Anu Asnaani, Otto, M.W., Michael W. Otto, Hofmann, S.G., Cassidy A. Gutner, Gutner, C.A., Jasper A.J. Smits, Stefan G. Hofmann, Smits, J.A.J., Asnaani, A.   +9 more
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Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome. [PDF]

, 2015
Enhancers can regulate the transcription of genes over long genomic distances. This is thought to lead to selection against genomic rearrangements within such regions that may disrupt this functional linkage.
Rinkwitz, S, Bally-Cuif, Laure, Chilamakuri, Chandra S R, Wilson, David I., Ishibashi, M, Rinkwitz, Silke, Wilson, SW, Crollius, H. R., Hawkins, Thomas A., Becker, Thomas S, Wilson, Stephen W., Strähle, U., Becker, TS, Rastegar, S., Lenhard, B., Hawkins, TA, Raymond, F. L., Chilamakuri, CS, Hawkins, T. A., Louis, A., Louis, A, Louis, Alexandra, Wilson, D. I., Chilamakuri, Chandra S. R., Hawkins, Thomas A, Ishibashi, Minaka, Crollius, Hugues Roest, Naville, M., Strähle, U, Wilson, S. W., Rastegar, Sepand, Lenhard, Boris, Becker, Thomas S., Straehle, Uwe, Manning, E, Bally-Cuif, L., FitzPatrick, David R., Bengani, H, Manning, E., Rastegar, S, Ferg, M, Roest Crollius, Hugues, Heyningen, V. van, Roest Crollius, H, Ferg, Marco, Bengani, Hemant, Lucy Raymond, F., Lucy Raymond, F, Naville, Magali, Krecsmarik, Monika, FitzPatrick, D. R., Bengani, H., Chilamakuri, C. S. R., Wilson, Stephen W, Ishibashi, M., Naville, M, Wilson, David I, van Heyningen, V, Bally-Cuif, L, Wilson, DI, Rinkwitz, S., Strähle, Uwe, Chilamakuri, Chandra Sekhar Reddy, FitzPatrick, DR, Raymond, F. Lucy, Ferg, M., Krecsmarik, M, Becker, T. S., van Heyningen, Veronica, Lenhard, B, Manning, Elizabeth, Krecsmarik, M., Fitzpatrick, David R   +72 more
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daler/chromhmm-enhancers-umel: v1.0

, 2017
Identify enhancers.
Ryan Dale
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Moral and social reasons to acknowledge the use of cognitive enhancers in competitive-selective contexts [PDF]

, 2016
Background: Although some of the most radical hypothesis related to the practical implementations of human enhancement have yet to become even close to reality, the use of cognitive enhancers is a very tangible phenomenon occurring with increasing ...
Lavazza A., Garasic M. D.
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Typical Enhancers, Super-Enhancers, and Cancers

, 2022
Non-coding segments of the human genome are enriched in cis-regulatory modules that constitute functional elements, such as transcriptional enhancers and Super-enhancers.
Champezou, L., Koutsi, M.A., Piperi, C., Vatsellas, G., Agelopoulos, M., Pouliou, M., Giannopoulou, A.-I.   +6 more
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Promise and Challenges in Drug Development and Assessment for Cognitive Enhancers

, 2017
Cognitive disturbances are ubiquitous in neurologic and psychiatric disorders. Schizophrenia, depression, developmental disorders, acquired brain disorders (traumatic brain injury and stroke), and neurodegenerative disorders all have cognitive impairment
Kate Zhong, Jeffrey Cummings
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The potential of HDAC inhibitors as cognitive enhancers [PDF]

Histone acetylation is a prominent epigenetic modification of the central nervous system that is unequivocally associated with an increase in the rate of gene transcription.
Gräff, Johannes, Tsai, Li-Huei
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Non-pharmacological cognitive enhancement

, 2013
Item does not contain fulltextThe term "cognitive enhancement" usually characterizes interventions in humans that aim to improve mental functioning beyond what is necessary to sustain or restore good health.
Dresler, M., Kuhn, S., Bublitz, C., Trenado, C., Sandberg, A., Kuehn, S., Mroczko-Wasowicz, A., Repantis, D., Ohla, K., Kühn, S. ; https://orcid.org/   +9 more
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GluN2A NMDA Receptor Enhancement Improves Brain Oscillations, Synchrony, and Cognitive Functions in Dravet Syndrome and Alzheimer’s Disease Models [PDF]

, 2020
Hanson et al. examine the therapeutic effects of enhancing GluN2A-subunit-containing NMDAR function in Dravet syndrome and Alzheimer's disease mice. GNE-0723 treatment reduces aberrant low-frequency oscillations and epileptiform discharges and improves ...
Yu, Gui-Qiu, Solanoy, Hilda, Jiang, Zhiyu, Sheng, Morgan, Saillet, Sandrine, Chan, Connie, Liu, Benjamin, Khan, Abdullah S, Weimer, Robby M, Schwarz, Jacob B, Elstrott, Justin, Ma, Keran, Liederer, Bianca M, Hackos, David H, Wang, Tzu-Ming, Palop, Jorge J, Kim, Thomas A, Scearce-Levie, Kimberly, Hanson, Jesse E, Volgraf, Matthew, Sellers, Benjamin D, Chen, Yelin, Gill, T Michael, Weber, Martin, Deshmukh, Gauri, Simms, Jeffrey   +25 more
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Can cognitive enhancers reduce the risk of falls in older people with Mild Cognitive Impairment? A protocol for a randomised controlled double blind trial [PDF]

, 2009
Background Older adults with cognitive problems have a higher risk of falls, at least twice that of cognitively normal older adults. The consequences of falls in this population are very serious: fallers with cognitive problems suffer more injuries due ...
Borrie Michael J, Jennie L Wells, Wells Jennie L, Michael J Borrie, Mark Speechley, Speechley Mark, Montero-Odasso Manuel, Manuel Montero-Odasso   +7 more
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