Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Le projet gnomAD montre l’importance de ne pas avoir qu’un seul génome humain de référence !
Bourgeron, Thomas
doaj +1 more source
How Does the Cerebral Cortex Work? Developement, Learning, Attention, and 3D Vision by Laminar Circuits of Visual Cortex [PDF]
A key goal of behavioral and cognitive neuroscience is to link brain mechanisms to behavioral functions. The present article describes recent progress towards explaining how the visual cortex sees.
Grossberg, Stephen
core +1 more source
Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim +3 more
wiley +1 more source
Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source
The Comparison of the Executive-Neurological Functions of the Narcotic Addicted and Normal Adults
Aim: The purpose of present research was the comparison of executive-neurological functions of narcotics addicted and normal adults. Method: In this causal-comparative study 38 narcotics addicted person selected of two addiction treatment clinics in ...
Fereshteh Amini +2 more
doaj
Background Given the increasing prevalence of Mild Cognitive Impairment (MCI) among the elderly as a precursor to dementia, understanding how targeted interventions can improve daily functioning and delay cognitive decline is critical to improving ...
Kevser Gursan, Kılıchan Bayar
doaj +1 more source
Neural correlates of cognitive intervention in persons at risk of developing Alzheimer's disease. [PDF]
Cognitive training is an emergent approach that has begun to receive increased attention in recent years as a non-pharmacological, cost-effective intervention for Alzheimer's disease (AD).
Hosseini, SM Hadi +2 more
core +1 more source
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu +11 more
wiley +1 more source
Cognitive functions of patients with epilepsy treated by topiramate [PDF]
Topiramate is a newer drug with a strong antiepileptic potential, but also with adverse effects, especially on cognitive functions. This review deals with the study covering the impact of topiramate on cognition in patients with epilepsy. The most common
Milošević Nenad +5 more
doaj

